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6-Mercaptopurine is a thiopurine antimetabolite; it exhibits immunosuppressive, anti-inflammatory, and anticancer chemotherapeutic activities. This compound is clinically used to treat inflammatory bowel disorder (IBD), Crohn’s disease, and leukemias and lymphomas. This compound suppresses metabolism of inosine monophosphate (IMP), inhibiting phosphoribosylpyrophosphate amidotransferase; this prevents synthesis of purines, DNA, and RNA.
| Cas No. | 6112-76-1 |
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| Purity | ≥98% |
| Formula | C5H4N4S • H2O |
| Formula Wt. | 170.20 |
| Chemical Name | 1,7-Dihydro-6H-pyrine-6-thione |
| IUPAC Name | 3,7-dihydropurine-6-thione;hydrate |
| Synonym | Purine-6-thiol, 6MP, Leukerin Mercaleukin, Purinethol: 6-Purinethiol |
| Melting Point | 313-314°C(dec.) |
| Solubility | Insoluble in water. Soluble in methanol and hot ethanol. |
| Appearance | Yellow Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Bradford K, Shih DQ. Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease. World J Gastroenterol. 2011 Oct 7;17(37):4166-73. PMID: 22072847.
Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther. 2001 Nov;15(11):1699-708. PMID: 11683683.
Lennard L, Welch JC, Lilleyman JS. Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br J Clin Pharmacol. 1997 Nov;44(5):455-61. PMID: 9384462.