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A-769662 is an activator of AMPK that is used in research models to study signaling mechanisms involved in cellular homeostasis. A-769662 exhibits anticancer and antithrombotic activities. In prostate cancer cells, this compound inhibits cellular proliferation, migration, and invasion. In osteoblasts, A-769662 inhibits H202-induced apoptosis and decreases accumulation of ROS. Additionally, it also decreases platelet aggregation in vitro.
| Cas No. | 844499-71-4 |
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| Purity | ≥98% |
| Formula | C20H12N2O3S |
| Formula Wt. | 360.39 |
| IUPAC Name | 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile |
| Solubility | DMSO 72 mg/mL (199.78 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Grey-tan powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kim J, Shin J, Ha J. Screening methods for AMP-activated protein kinase modulators: a patent review. Expert Opin Ther Pat. 2015 Mar;25(3):261-77. PMID: 25535089.
Choudhury Y, Yang Z, Ahmad I, et al. AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience. 2014 Jun 4;1(6):446-56. PMID: 25594043.
Zhu Y, Zhou J, Ao R, et al. A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase (AMPK). Int J Mol Sci. 2014 Jun 23;15(6):11190-203. PMID: 24960362.
Liu Y, Oh SJ, Chang KH, et al. Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole. Biochem Pharmacol. 2013 Oct 1;86(7):914-25. PMID: 23876340.