Description
AB-680 is an inhibitor of CD73, which plays a key role in tumor growth, metastasis, and tumor-associated macrophage upregulation.
AB-680
Product ID A040068
Cas No. 2105904-82-1
Purity ≥98%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 2105904-82-1 |
|---|---|
| Purity | ≥98% |
| Formula | C20H24ClFN4O9P2 |
| Formula Wt. | 580.83 |
| IUPAC Name | [[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid |
| Synonym | AB680, Quemliclustat |
| Appearance | Off white powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Faraoni E, Strickland L, O’Brien B, et al. Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma. Front Oncol. 2022 Sep 6;12:995027. PMID: 36147911
Noh J, Lee I, Han N, et al. Additive effect of CD73 inhibitor in colorectal cancer treatment with CDK4/6 inhibitor through regulation of PD-L1. Cell Mol Gastroenterol Hepatol. 2022;14(4):769-788. PMID: 35843546
Kim M, Min Y, Jang J, et al. Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer. J Immunother Cancer. 2021 Jul;9(7):e002503. PMID: 34253638