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Aconitine

Aconitine

Product ID A0958
Cas No. 302-27-2
Purity ≥95%
Product Unit SizeCostQuantityStock
10 mg $76.90 In stock
25 mg $134.30 In stock
100 mg $420.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis. Aconitine acts as a positive inotrope, potentially inducing cardiac arrhythmia.

Product Info

Cas No.

302-27-2

Purity

≥95%

Formula

C34H47NO11

Formula Wt.

645.74

Chemical Name

(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy- 4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate

IUPAC Name

[(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate

Synonym

20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoate: Acetylbenzoylaconine

Melting Point

204°C

Solubility

Soluble in water (0.3 mg/mL) or ethanol (35 mg/mL).

Appearance

White Crystal

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A0958 MSDS PDF

Info Sheet

A0958 Info Sheet PDF

References

Chan TY. Aconite poisoning. Clin Toxicol (Phila). 2009 Apr;47(4):279-85. PMID: 19514874.

Gutser UT, Friese J, Heubach JF, et al. Mode of antinociceptive and toxic action of alkaloids of Aconitum spec. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):39-48. PMID: 9459571.

Okazaki M, Kimura I, Kimura M. Aconitine-induced increase and decrease of acetylcholine release in the mouse phrenic nerve-hemidiaphragm muscle preparation. Jpn J Pharmacol. 1994 Dec;66(4):421-6. PMID: 7723217.

Custom Order

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