LKT Labs

Biochemicals for Life Science Research

Actinomycin

Actinomycin

Product ID A0977
Cas No. 50-76-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
10 mg $208.00 In stock
Bulk Quote

Quicklinks

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.

50-76-0
Purity

≥98%
Formula

C62H86N12O16
Formula Wt.

1255.50
IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym

Actinomycin D, Meractinomycin, Dactinomycin
Melting Point

245-255°C (dec.)
Solubility

Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance

Salmon Pink Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A0977 MSDS PDF
Info Sheet

A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0393

    (+/-)-Taxifolin Hydrate

    Catechol-type flavonoid.

    ≥95%
  • B0025

    Bafilomycin A1

    Macrolide antibiotic; vacuolar H+ ATPase inhibi...

    ≥90%
  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • I6933

    Irinotecan Hydrochloride Trihydrate

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • T1008

    10,13-Bissidechain Paclitaxel

    Synthesis impurity

    ≥90%
  • T3099

    Thymus Factor

    Endogenous peptide, involved in immune signalin...

    ≥95%
  • A1218

    Adefovir Dipivoxil

    Acyclic nucleotide (adenosine) analog, adefovir...

    ≥98%
  • F4483

    Flufenamic Acid

    NSAID; TREK1 K+ potentiator, voltage-gated Na+ ...

    ≥97%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • L1782

    Levodopa

    Endogenous catecholamine precursor, also found ...

    ≥98%
  • L0400

    LB-100

    PP2A inhibitor.

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • I0480

    Ibudilast

    PDE3/5 inhibitor, LTD4 antagonist.

    ≥98%
  • W2800

    WH-4-023

    Lck, Src, SIK inhibitor.

    ≥99 %
  • A745817

    Asunaprevir

    Antiviral againt SARS-CoV-2

    ≥98%
  • R5745

    Rolipram

    Anxiolytic-like agent that stimulates angiogene...

    ≥98%
  • C4533

    Clindamycin Phosphate

    Lincosamide; ribosomal translocation and protei...

    ≥98%
  • D5607

    Dobutamine Hydrochloride

    β1-adrenergic agonist, β2- and α1-adrenergic...

    ≥98%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%