LKT Labs

Biochemicals for Life Science Research

Actinomycin

Actinomycin

Product ID A0977
Cas No. 50-76-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
10 mg $208.00 In stock
Bulk Quote

Quicklinks

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.

50-76-0
Purity

≥98%
Formula

C62H86N12O16
Formula Wt.

1255.50
IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym

Actinomycin D, Meractinomycin, Dactinomycin
Melting Point

245-255°C (dec.)
Solubility

Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance

Salmon Pink Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A0977 MSDS PDF
Info Sheet

A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • K0552

    Kb NB 77-78

    CID-797718 analog; potential PKD1 binding agent...

    ≥98%
  • R6052

    Recombinant Mycoplasma Pneumonia Antigen

    Pneumonia antigen
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • P7103

    Praziquantel

    Alters membrane permeability and Ca2+ signaling...

    ≥98%
  • M0114

    Madecassic Acid

    Downregulates LPS-stimulated expression of pro-...

    ≥95%
  • G3460

    Ginsenoside F1

    Triterpene saponin found in species of Panax.

    ≥98%
  • D1859

    2-Deoxy-D-glucose

    Glucose metabolism inhibitor, N-linked glycosyl...

    ≥99%
  • O1179

    n-Octyl-4-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • S7603

    Stavudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥99%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%
  • S680000

    SR144528

    Selective cannabinoid receptor 2 (CB2) inverse ...

    ≥98%
  • D3449

    Dimethoxycurcumin

    Curcumin derivative.

    ≥98%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • A6934

    Aristolochic Acid C

    Found in Aristolochia and Radix; potential PLA2...

    ≥94%
  • A0902

    N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; HDAC inhib...

    ≥98%
  • J974440

    JZL184

    MAGL inhibitor.

    ≥98%
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%