LKT Labs

Biochemicals for Life Science Research

Actinomycin

Actinomycin

Product ID A0977
Cas No. 50-76-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
10 mg $208.00 In stock
Bulk Quote

Quicklinks

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.

50-76-0
Purity

≥98%
Formula

C62H86N12O16
Formula Wt.

1255.50
IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym

Actinomycin D, Meractinomycin, Dactinomycin
Melting Point

245-255°C (dec.)
Solubility

Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance

Salmon Pink Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A0977 MSDS PDF
Info Sheet

A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2512

    S-(N-Phenethylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • N5769

    Norfloxacin Nicotinate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • L1784

    Levetiracetam

    SV2A synaptic vesicle inhibitor.

    ≥99%
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • A5161

    Ampiroxicam

    Piroxicam prodrug, NSAID; COX-1/2 inhibitor.

    ≥98%
  • M9608

    Myclobutanil

    14-α demethylase inhibitor.

    ≥97%
  • G8850

    GW-5074

    c-Raf inhibitor.

    ≥98%
  • M184774

    5-(Methylsulfinyl)pentyl Nitrile

    Synthetic compound related to sulforaphane.

    ≥98%
  • J974440

    JZL184

    MAGL inhibitor.

    ≥98%
  • I7557

    1-Isothiocyanato-6-(methylsulfonyl)-hexane

    Synthetic ITC, erysolin analog.

    ≥98%
  • S3453

    Sinigrin Monohydrate, synthetic

    ITC precursor found in cruciferous vegetables.<...

    ≥98%
  • M1746

    Melphalan

    Nitrogen mustard, DNA alkylator.

    ≥95%
  • H9611

    Hydrocortisone

    Endogenous steroid hormone involved in stress s...

    ≥98%
  • S5976

    Sotalol Hydrochloride

    β-adrenergic antagonist, voltage-gated Na+ and...

    ≥98%
  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • C3250

    Cimetidine

    Histamine H2 and AR antagonist, catalase inhibi...

    ≥99%
  • B1640

    Benzydamine Hydrochloride

    NSAID; PG synthetase inhibitor.

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%