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AdipoRon

AdipoRon

Product ID A1334
Cas No. 924416-43-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $157.50 Please Inquire
50 mg $630.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AdipoRon is an agonist at adiponectin receptors that increases secretion of AMPK and PPAR-α. AdipoRon exhibits anti-diabetic and cardioprotective activities and is in development as a potential treatment for type 2 diabetes mellitus (T2DM). In vivo, AdipoRon decreases insulin resistance and glucose tolerance, ameliorates diabetes, and increases lifespan. In animal models of myocardial ischemia/reperfusion, this compound improves cardiac function, decreases oxidative stress, and inhibits post-ischemic cardiomyocyte apoptosis.

Product Info

Cas No.

924416-43-3

Purity

≥98%

Formula

C27H28N2O3

Formula Wt.

428.53

Chemical Name

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide

IUPAC Name

2-(4-Benzoylphenoxy)-N-(1-benzyl-4-piperidinyl)acetamide

Synonym

SC-396658

Solubility

Soluble in DMSO, 100% ethanol or methanol. Insoluble in water

Appearance

White solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A1334 MSDS PDF

Info Sheet

A1334 Info Sheet PDF

References

Zhang Y, Zhao J, Li R, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.PMID: 26037251.

Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PMID: 24172895.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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