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Adrenomedullin is an endogenous peptide hormone involved in growth and differentiation of stem cells. This peptide exhibits vasodilatory, natriuretic, and cardioprotective activities. Adrenomedullin decreases blood pressure and increases neovascularization. This peptide binds microtubule-associated proteins in the cytoskeleton and also activates CLR-RAMP receptors, regulating vascular tone and cardiovascular development.
| Cas No. | 148498-78-6 |
|---|---|
| Purity | ≥95% |
| Formula | C264H406N80O77S3 |
| Formula Wt. | 6028.9 |
| Solubility | Soluble in water, acid. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Larráyoz IM, Martínez-Herrero S, Ochoa-Callejero L, et al. Is the cytoskeleton an intracellular receptor for adrenomedullin and PAMP? Curr Protein Pept Sci. 2013 Aug;14(5):429-43. PMID: 23745706.
Chang CL, Hsu SY. Roles of CLR/RAMP receptor signaling in reproduction and development. Curr Protein Pept Sci. 2013 Aug;14(5):393-406. PMID: 23745703.
Shindo T, Sakurai T, Kamiyoshi A, et al. Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice. Curr Protein Pept Sci. 2013 Aug;14(5):347-57. PMID: 23745699.
Larrayoz IM, Ochoa-Callejero L, García-Sanmartín J, et al. Role of adrenomedullin in the growth and differentiation of stem and progenitor cells. Int Rev Cell Mol Biol. 2012;297:175-234. PMID: 22608560.
Wong HK, Cheung TT, Cheung BM. Adrenomedullin and cardiovascular diseases. JRSM Cardiovasc Dis. 2012 Aug 10;1(5). PMID: 24175071.