LKT Labs

Biochemicals for Life Science Research

Adrenorphin

Adrenorphin

Product ID A1371
Cas No. 88377-68-8
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $98.40 Please Inquire
2 mg $167.80 Please Inquire
5 mg $294.60 Please Inquire
Bulk Quote

Quicklinks

Description

Adrenorphin is an endogenous opioid peptide produced from cleavage of proenkephalin A. Adrenorphin acts as an agonist at κ-opioid receptors (κORs) and μ-opioid receptors (μORs). Like other opioids, adrenorphin exhibits analgesic, antinociceptive, and gastrointestinal motility modulating activities. Adrenorphin also causes respiratory depression in animal models. In pheochromocytoma cells, adrenorphin inhibits catecholamine secretion. In animal models, it also inhibits urinary bladder muscle contractions.

Product Info

Cas No.

88377-68-8
Purity

≥95%
Formula

C44H69N15O9S
Formula Wt.

984.2
IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-N-[(2R)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-(diaminomethylideneamino)pentanamide
Synonym

Metorphamide
Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A1371 MSDS PDF
Info Sheet

A1371 Info Sheet PDF

References

Yanase T, Nawata H, Kato K,et al. Studies on adrenorphin in pheochromocytoma. J Clin Endocrinol Metab. 1987 Apr;64(4):692-7. PMID: 3818899.

Xu SF, Lu WX, Zhou KR, et al. The analgesic and respiratory depressant actions of metorphamide in mice and rabbits. Neuropeptides. 1985 Apr;6(2):121-31. PMID: 4000426.

Dray A, Davis TP. The proenkephalin A fragment metorphamide shows supraspinal and spinal opioid activity in vivo. Peptides. 1985 Mar-Apr;6(2):217-21. PMID: 3839922.

Weber E, Esch FS, Böhlen P, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6. PMID: 6316361.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0142

    TAK-733

    MEK inhibitor.

    ≥98%
  • K9200

    KX1-004

    Indole; Src inhibitor.

    ≥98%
  • O4417

    Oleanolic Acid

    Triterpenoid found in Vigna angularis and Trigo...

    ≥98%
  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective....

    ≥98%
  • A1607

    AEBSF Hydrochloride

    Serine protease substrate/inhibitor.

    ≥98%
  • P3456

    Pimobendan

    PDE3 inhibitor.

    ≥99%
  • T0094

    2′,7-Bisacetyltaxol

    Taxane synthesis intermediate.

    ≥96%
  • B3577

    Bitertanol

    Pesticide; demethylation inhibitor.

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • H9618

    Hydroquinone

    Basic phenol skeleton structure found in variou...

    ≥96%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • D324104

    Diclofenac Chloroacetyl impurity

    Impurity of diclofenac

    ≥99%
  • A6264

    Apramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • T291321

    Thiamine Mononitrate

    Vitamin B1

    ≥98%
  • B8276

    Butyric Acid Sodium

    HDAC inhibitor, RNA splicing modulator.

    ≥98%
  • A9602

    Azacitidine

    Nucleoside (cytidine) analog; DNMT inhibitor, p...

    ≥98%
  • A064766

    ABT 639

    T-type calcium channel blocker

    ≥99%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • O4400

    Olanzapine

    AMPK activator, D1-4, 5-HT1A/2/3/6/7, M1-5 mACh...

    ≥99%