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Afuresertib

Afuresertib

Product ID A225822
Cas No. 1047644-62-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $122.70 In stock
25 mg $374.90 In stock
100 mg $988.10 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Afuresertib is an inhibitor of Akt, a serine/threonine kinase. In addition to showing efficacy in clinical trials as a monotherapy against hematological malignancies, afuresertib has been effective against multiple myeloma. When used in combination with pomalidomide plus dexamethasone, afuresertib exhibited antitumor activity in multiple myeloma cells. It has also shown efficacy in patients with malignant pleural mesothelioma.

Product Info

Cas No.

1047644-62-1

Purity

≥98%

Formula

C18H17Cl2FN4OS

Formula Wt.

427.32

IUPAC Name

N-[(2S)-1-Amino-3-(3-fluorophenyl)-2-propanyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide

Synonym

GSK-2110183C, GSK-2110183

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A225822 MSDS PDF

Info Sheet

A225822 Info Sheet PDF

References

Kinoshita S., Ri M., et al. Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma. Oncol Lett. 15(6):9450-56 (2018). PMID: 29927335.

Yamaji M., Ota A., et al. Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 6(11):2646-59 (2017). PMID: 28960945.

Custom Order

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