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Allopurinol

Allopurinol

Product ID A4445
Cas No. 315-30-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $39.00 In stock
10 g $45.50 In stock
50 g $64.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Allopurinol is a purine analog that mimics hypoxanthine, inhibiting xanthine oxidase; it is clinically used to treat diseases of hyperuricemia, such as gout. Allopurinol exhibits anti-inflammatory, nephroprotective, antinociceptive, antioxidative, anti-fibrotic, and cardioprotective activities. In animal models of renal ischemia, allopurinol decreases production of inflammatory cytokines. In other animal models, allopurinol decreases oxidative stress, suppresses atrial fibrosis, and prevents atrial fibrillation. Additionally, this compound also decreases nociception in animal models of thermal and chemical pain, likely due to increasing levels of hypoxanthine and xanthine, which are metabolized downstream to form adenosine.

Product Info

Cas No.

315-30-0

Purity

≥98%

Formula

C5H4N4O

Formula Wt.

136.11

Chemical Name

1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

IUPAC Name

1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

Synonym

Adenock, Apurol, Allozym, Apurin, Bloxanth, Embarin, Gichtex, Ketanrift, Lysuron, Urosin, Zyloric

Melting Point

>350°C

Solubility

20mg/mL in DMSO 0.5mg/mL in MeOH 0.30 mg/mL in EtOH 0.48 mg/mL in water

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A4445 MSDS PDF

Info Sheet

A4445 Info Sheet PDF

References

Prieto-Moure B, Carabén-Redaño A, Aliena-Valero A, et al. Allopurinol in renal ischemia. J Invest Surg. 2014 Oct;27(5):304-16. PMID: 24914485.

Essawy SS, Elbaz AA. Role of adenosine receptors in the anti-nociceptive effects of allopurinol in mice. Eur Rev Med Pharmacol Sci. 2013 Jul;17(14):1857-63. PMID: 23877847.

Sakabe M, Fujiki A, Sakamoto T, et al. Xanthine oxidase inhibition prevents atrial fibrillation in a canine model of atrial pacing-induced left ventricular dysfunction. J Cardiovasc Electrophysiol. 2012 Oct;23(10):1130-5. PMID: 22587612.

Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. PMID: 16507884.

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