Alternariol-9-methyl Ether

Name: Alternariol-9-methyl Ether
SKU: A4678
Availability: InStock

Product ID A4678

Cas No. 26894-49-5; 23452-05-3

Purity ≥98%

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Description

Alternariol 9-methyl ether (A9ME) is a highly toxic mutagenic phytotoxin initially produced by species of Alternaria. A9ME is present in grain and fruit used for livestock feed and human consumption. A9ME inhibits the electron transport chain, preventing photosynthesis in vitro. Additionally, A9ME may exhibit anticancer potential in a cellular model of colon carcinoma, as it decreases the mitochondrial membrane potential, increasing release of cytochrome c and activating caspases 3 and 9; this results in apoptosis and cell death.

Product Info

Cas No.	26894-49-5; 23452-05-3
Purity	≥98%
Formula	C₁₅H₁₂O₅
Formula Wt.	272.25
Chemical Name	6H-Dibenzo(b,d)pyran-6-one, 3,7-dihydroxy-9-methoxy-1-methyl
IUPAC Name	3,7-dihydroxy-9-methoxy-1-methylbenzo[c]chromen-6-one
Synonym	AME; Djalonensone; Alternariol monomethyl ether; Alternariol methyl ether; Alternariol-9-methyl ether
Solubility	Soluble in DMSO, ethanol, methanol
Appearance	Beige Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	A4678 MSDS PDF
Info Sheet	A4678 Info Sheet PDF

References

Demuner AJ, Barbosa LC, Miranda AC, et al. The Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain. J Nat Prod. 2013 Nov 18. [Epub ahead of print]. PMID: 24245962.

Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.

Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.

Bensassi F, Gallerne C, el Dein OS, et al. Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells. Toxicology. 2011 Dec 18;290(2-3):230-40. PMID: 22001388.

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Alternariol-9-methyl Ether

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Description

Product Info

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References

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