LKT Labs

Biochemicals for Life Science Research

Alternariol-9-methyl Ether

Alternariol-9-methyl Ether

Product ID A4678
Cas No. 26894-49-5; 23452-05-3
Purity ≥98%
Product Unit SizeCostQuantityStock
0.1 mg $54.60 In stock
1 mg $330.60 Please Inquire
5 mg $1,277.00 Please Inquire
Bulk Quote

Quicklinks

Description

Alternariol 9-methyl ether (A9ME) is a highly toxic mutagenic phytotoxin initially produced by species of Alternaria. A9ME is present in grain and fruit used for livestock feed and human consumption. A9ME inhibits the electron transport chain, preventing photosynthesis in vitro. Additionally, A9ME may exhibit anticancer potential in a cellular model of colon carcinoma, as it decreases the mitochondrial membrane potential, increasing release of cytochrome c and activating caspases 3 and 9; this results in apoptosis and cell death.

Product Info

Cas No.

26894-49-5; 23452-05-3
Purity

≥98%
Formula

C15H12O5
Formula Wt.

272.25
Chemical Name

6H-Dibenzo(b,d)pyran-6-one, 3,7-dihydroxy-9-methoxy-1-methyl
IUPAC Name

3,7-dihydroxy-9-methoxy-1-methylbenzo[c]chromen-6-one
Synonym

AME; Djalonensone; Alternariol monomethyl ether; Alternariol methyl ether; Alternariol-9-methyl ether
Solubility

Soluble in DMSO, ethanol, methanol
Appearance

Beige Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4678 MSDS PDF
Info Sheet

A4678 Info Sheet PDF

References

Demuner AJ, Barbosa LC, Miranda AC, et al. The Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain. J Nat Prod. 2013 Nov 18. [Epub ahead of print]. PMID: 24245962.

Broggi L, Reynoso C, Resnik S, et al. Occurrence of alternariol and alternariol monomethyl ether in beverages from the Entre Rios Province market, Argentina. Mycotoxin Res. 2013 Feb;29(1):17-22. PMID: 23334721.

Scott PM, Zhao W, Feng S, et al. Alternaria toxins alternariol and alternariol monomethyl ether in grain foods in Canada. Mycotoxin Res. 2012 Nov;28(4):261-6. PMID: 23087499.

Bensassi F, Gallerne C, el Dein OS, et al. Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells. Toxicology. 2011 Dec 18;290(2-3):230-40. PMID: 22001388.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R2513

    RGDS

    Tetrapeptide, binds cell surface integrins.

    ≥95%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • A4498

    Alytesin

    Antimicrobial peptide found in amphibians.

    ≥95%
  • L1044

    LCL-161

    SMAC mimetic; PXR agonist, IAP inhibitor.

    ≥99%, ≥99%ee, de
  • C5771

    Corticosterone

    Endogenous steroid hormone involved in immune r...

    ≥98%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • T8153

    Tunicamycin

    Nucleoside antibiotic mixture; GlcNAc phosphotr...

    ≥98%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • C0253

    Candesartan

    AT1 inhibitor.

    ≥98%
  • E0001

    E64

    Cysteine protease inhibitor.

    ≥99%
  • T0115

    Taxol Side Chain Acid

    Side chain commonly attached to taxanes.

    ≥98%
  • T3032

    Thienyldecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • E4444

    Ellagic Acid

    Phenol found in various fruits; HDAC modulator....

    ≥98%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • L302690

    LHRH Acetate Salt

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • M1560

    Methyl Caffeate

    Polyphenol found in species of Solanum and Magn...

    ≥98%
  • M4452

    MLN2480

    Raf inhibitor.

    ≥98%