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Amiloride Hydrochloride Dihydrate

Amiloride Hydrochloride Dihydrate

Product ID A5133
Cas No. 17440-83-4
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $69.70 In stock
1 g $93.90 In stock
5 g $340.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amiloride is a potassium-sparing diuretic that exhibits antihypertensive and antiviral activities. Amiloride inhibits epithelial Na+ channels (ENaCs), acid-sensing ion channels, and Na+/H+ antiporters. Amiloride prevents Na+ reabsorption in the kidney, increasing excretion of Na+ and water; it is clinically used to treat hypertension and congestive heart failure (CHF). In vitro, amiloride inhibits replication of Coxsackievirus B3 and poliovirus type 1.

Product Info

Cas No.

17440-83-4

Purity

≥98%

Formula

C6H8ClN7O • HCl • 2H2O

Formula Wt.

302.12

Chemical Name

3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazine-carboxamide hydrochloride

IUPAC Name

3, 5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; dihydrate;hydrochloride

Synonym

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride, Amiprazidine

Melting Point

285-288°C

Solubility

Soluble in water.

Appearance

Light yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5133 MSDS PDF

Info Sheet

A5133 Info Sheet PDF

References

Ogram SA, Boone CD, McKenna R, et al. Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation. Virology. 2014 Sep;464-465:87-97. PMID: 25058507.

Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8. PMID: 24994852.

Paar M, Pavenstädt H, Kusche-Vihrog K, et al. Endothelial sodium channels trigger endothelial salt sensitivity with aging. Hypertension. 2014 Aug;64(2):391-6. PMID: 24866143.

Bhagatwala J, Harris RA, Parikh SJ, et al. Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives. J Clin Hypertens (Greenwich). 2014 Jan;16(1):47-53. PMID: 24410943.

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