LKT Labs

Biochemicals for Life Science Research

Amiodarone Hydrochloride

Product ID A5037
Cas No. 19774-82-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $66.90 In stock
5 g $227.70 In stock
10 g $374.50 In stock
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Description

Amiodarone is a class III anti-arrhythmic that inhibits Na+ channels, voltage-gated Ca2+ channels, voltage-gated K+ channels, and α/β-adrenergic receptors. Amiodarone prolongs the duration of the action potential, increasing the length of the refractory period; it is clinically used to treat ventricular fibrillation and ventricular tachycardia. Amiodarone also exhibits antiviral activity, inhibiting cell entry by filovirus, guanarito virus, and hepatitis C. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

19774-82-4
Purity

≥98%
Formula

C25H29I2NO3 • HCl
Formula Wt.

681.78
Chemical Name

(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride
IUPAC Name

(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3, 5-diiodophenyl]methanone;hydrochloride
Synonym

Amiodar, Ancaron, Cordarone, Ortacrone, Tachydaron, Trangorex  

Melting Point

156°C

Solubility

Soluble in methanol, chloroform, and methylene chloride. Slightly soluble in acetone and dioxane. Sparingly soluble in isopropanol.

Appearance

White or almost white Crystal Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A5037 MSDS PDF
Info Sheet

A5037 Info Sheet PDF

References

Zoerner F, Semenas E. Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs. J Trauma Acute Care Surg. 2014 Jun;76(6):1402-8. PMID: 24854308.

Gehring G, Rohrmann K, Atenchong N, et al. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. J Antimicrob Chemother. 2014 Apr 7. [Epub ahead of print]. PMID: 24710028.

Cheng YL, Lan KH, Lee WP, et al. Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle. Clin Sci (Lond). 2013 Nov;125(9):439-48. PMID: 23659500.

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