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Amlodipine Besylate

Amlodipine Besylate

Product ID A5044
Cas No. 111470-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $102.00 In stock
5 g $408.30 In stock
10 g $547.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats.

Product Info

Cas No.

111470-99-6

Purity

≥98%

Formula

C20H25ClN2O5 • C6H5SO3H

Formula Wt.

567.06

Chemical Name

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

IUPAC Name

benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3,5-dicarboxylate

Synonym

Amlodipine Benzenesulfonate, Amlor, Istin, Monopina, Norvasc

Melting Point

195-204°C

Solubility

Slightly soluble in water. Sparingly soluble in ethanol. soluble in DMSO(113mg/ml)

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5044 MSDS PDF

Info Sheet

A5044 Info Sheet PDF

References

Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067.

Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000.

Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100.

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