• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Anagrelide

Anagrelide

Product ID A5327
Cas No. 68475-42-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $127.90 In stock
25 mg $217.90 In stock
100 mg $563.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Anagrelide is an imidazoquinazoline anti-platelet compound that inhibits platelet aggregation at high doses and decreases platelet activity at low doses. Anagrelide inhibits phosphodiesterase III (PDE3). Anagrelide also decreases expression of GATA-1 and FOG1, suppressing megakaryocytopoiesis; it shows benefit in the treatment of chronic myeloproliferative disorders such as thrombocythemia. In vitro, anagrelide inhibits thombopoietin-mediated cell differentiation.

Product Info

Cas No.

68475-42-3

Purity

≥98%

Formula

C10H7Cl2N3O

Formula Wt.

FW 256.09

Chemical Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

IUPAC Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

Melting Point

280°C

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5327 MSDS PDF

Info Sheet

A5327 Info Sheet PDF

References

Ahluwalia M, Donovan H, Singh N, et al. Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction. J Thromb Haemost. 2010 Oct;8(10):2252-61. PMID: 20586925.

McCarty JM, Melone PD, Simanis JP, et al. A preliminary investigation into the action of anagrelide: thrombopoietin-c-Mpl receptor interactions. Exp Hematol. 2006 Jan;34(1):87-96. PMID: 16413395.

Wang G, Franklin R, Hong Y, et al. Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. PMID: 16041400.

Tefferi A, Silverstein MN, Petitt RM, et al. Anagrelide as a new platelet-lowering agent in essential thrombocythemia: mechanism of actin, efficacy, toxicity, current indications. Semin Thromb Hemost. 1997;23(4):379-83. PMID: 9263355.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N3323

    Nifuratel

    Nitrofuran derivative.

    ≥99%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • R0272

    Rasagiline Mesylate

    MAO-A/B inhibitor.

    ≥98%
  • A5044

    Amlodipine Besylate

    Dihydropyridine, FIASMA; L-type Ca2+ channel bl...

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • S1059

    Scopolamine Hydrobromide Trihydrate

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • Q8139

    Quizartinib

    FLT3, c-Kit, PDGFR inhibitor.

    ≥98%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%
  • D582703

    Dorsomorphin

    Inhibitor of ALK2, ALK3, ALK6, and AMPK.

    ≥98%
  • M1676

    Methotrexate Hydrate

    DHF reductase inhibitor.

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • A1318

    Adenine

    Endogenous purine nucleotide base, required for...

    ≥98%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • I527211

    Infigratinib Phosphate

    FGFR inhibitor.

    ≥98%
  • C0267

    Carnosol

    Diterpene compound originally found in Rosmarin...

    ≥98%
  • S7970

    Strontium Ranelate

    Bone deterioration inhibitor, potential CaR ago...

    ≥98%
  • W0275

    R-(+)-Warfarin Sodium >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • T0115

    Taxol Side Chain Acid

    Side chain commonly attached to taxanes.

    ≥98%
  • A0978

    Actinonin

    Peptide deformylase, MMP meprin A, aminopeptida...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only