• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Anagrelide

Anagrelide

Product ID A5327
Cas No. 68475-42-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $127.90 In stock
25 mg $217.90 In stock
100 mg $563.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Anagrelide is an imidazoquinazoline anti-platelet compound that inhibits platelet aggregation at high doses and decreases platelet activity at low doses. Anagrelide inhibits phosphodiesterase III (PDE3). Anagrelide also decreases expression of GATA-1 and FOG1, suppressing megakaryocytopoiesis; it shows benefit in the treatment of chronic myeloproliferative disorders such as thrombocythemia. In vitro, anagrelide inhibits thombopoietin-mediated cell differentiation.

Product Info

Cas No.

68475-42-3

Purity

≥98%

Formula

C10H7Cl2N3O

Formula Wt.

FW 256.09

Chemical Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

IUPAC Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

Melting Point

280°C

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5327 MSDS PDF

Info Sheet

A5327 Info Sheet PDF

References

Ahluwalia M, Donovan H, Singh N, et al. Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction. J Thromb Haemost. 2010 Oct;8(10):2252-61. PMID: 20586925.

McCarty JM, Melone PD, Simanis JP, et al. A preliminary investigation into the action of anagrelide: thrombopoietin-c-Mpl receptor interactions. Exp Hematol. 2006 Jan;34(1):87-96. PMID: 16413395.

Wang G, Franklin R, Hong Y, et al. Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. PMID: 16041400.

Tefferi A, Silverstein MN, Petitt RM, et al. Anagrelide as a new platelet-lowering agent in essential thrombocythemia: mechanism of actin, efficacy, toxicity, current indications. Semin Thromb Hemost. 1997;23(4):379-83. PMID: 9263355.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S7717

    Sterigmatocystin

    Mycotoxin produced by Aspergillus; carcinogen.<...

    ≥98%
  • M0173

    Mastoparan X

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • U5232

    Uniconazole

    Triazole; gibberellin inhibitor, potential 14-...

    ≥98%
  • H014458

    Halometasone

    Glucocorticoid

    ≥98%
  • L302690

    LHRH Acetate Salt

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • R2514

    RGDV

    Tretraeptide, binds cell surface integrins.

    ≥98%
  • T0205

    3”,4”-Dehydropaclitaxel C

    Semi-synthetic taxane.

    ≥95%
  • L3453

    Linezolid

    Oxazolidinone; protein synthesis inhibitor.

    ≥99%
  • G124082

    GDC-0941

    pan-PI3K inhibitor.

    ≥98%
  • P7218

    Pseudoprotodioscin

    Steroidal saponin found in Tribulus, Trigonella...

    ≥98%
  • F441026

    Flavopiridol Hydrochloride

    Semisynthetic flavone that acts as an inhibitor...

    ≥98%
  • S8345

    S-(−)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥99%
  • N3346

    Nilotinib

    Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...

    ≥99%
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • B3209

    Bicalutamide

    AR antagonist.

    ≥98%
  • E7324

    Ethisterone

    Synthetic steroid hormone, contraceptive; PR ag...

    ≥98%
  • V014451

    Valiltramiprosate

    beta-Amyloid anti-oligomer and aggregation inhi...

    ≥99%
  • A480010

    AM630

    CB2 receptor antagonist.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only