• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Anagrelide

Anagrelide

Product ID A5327
Cas No. 68475-42-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $127.90 In stock
25 mg $217.90 In stock
100 mg $563.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Anagrelide is an imidazoquinazoline anti-platelet compound that inhibits platelet aggregation at high doses and decreases platelet activity at low doses. Anagrelide inhibits phosphodiesterase III (PDE3). Anagrelide also decreases expression of GATA-1 and FOG1, suppressing megakaryocytopoiesis; it shows benefit in the treatment of chronic myeloproliferative disorders such as thrombocythemia. In vitro, anagrelide inhibits thombopoietin-mediated cell differentiation.

Product Info

Cas No.

68475-42-3

Purity

≥98%

Formula

C10H7Cl2N3O

Formula Wt.

FW 256.09

Chemical Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

IUPAC Name

6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one

Melting Point

280°C

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5327 MSDS PDF

Info Sheet

A5327 Info Sheet PDF

References

Ahluwalia M, Donovan H, Singh N, et al. Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction. J Thromb Haemost. 2010 Oct;8(10):2252-61. PMID: 20586925.

McCarty JM, Melone PD, Simanis JP, et al. A preliminary investigation into the action of anagrelide: thrombopoietin-c-Mpl receptor interactions. Exp Hematol. 2006 Jan;34(1):87-96. PMID: 16413395.

Wang G, Franklin R, Hong Y, et al. Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. PMID: 16041400.

Tefferi A, Silverstein MN, Petitt RM, et al. Anagrelide as a new platelet-lowering agent in essential thrombocythemia: mechanism of actin, efficacy, toxicity, current indications. Semin Thromb Hemost. 1997;23(4):379-83. PMID: 9263355.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A9814

    AZD-4547

    FGFR inhibitor.

    ≥98%
  • U5232

    Uniconazole

    Triazole; gibberellin inhibitor, potential 14-Î...

    ≥98%
  • E6356

    Epothilone D

    Microtubule depolymerization inhibitor.

    ≥98%
  • H965142

    Hydrolyzed Fumonisin B1

    Mycotoxin produced by Fusarium fungi that infec...

    ≥99% by ELSD
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • M1777

    R-(−)-α-Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • P5845

    Polydatin

    Stilbenoid glucoside found in Polygonum.

    ≥97%
  • M3598

    Mizoribine Hydrobromide

    IMPDH inhibitor.

    ≥98%
  • H9816

    2-Hydroxyestradiol

    Estradiol metabolite.

    ≥99%
  • T286165

    Theaflavin-3-gallate

    Polyphenolic compound present in black tea.

    ≥95%
  • K4401

    KL-1 Peptide

    Peptide, c-Kit ligand fragment.

    ≥95%
  • A1331

    Adipokinetic Hormone, locust

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • C9709

    Cycloheximide

    Protein synthesis inhibitor, used to measure pr...

    ≥98%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • B8248

    Bumetanide

    Loop diuretic; NKCC symporter and KCC2 co-trans...

    ≥98%
  • C4535

    Clinafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • T0098

    10-Deacetyltaxol C

    Diterpene found in Taxus; potential microtubule...

    ≥97%
  • C8069

    Curcumin

    Diarylheptanoid found in Zingiberaceae.

    ≥97% curcuminoid content

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only