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This peptide is also known as bradykinin-potentiating peptide 9a; it exhibits vasodilatory and antihypertensive activity. This peptide inhibits angiotensin-converting enzyme (ACE) in vivo, decreasing blood pressure. This peptide also inhibits hydrolysis of bradykinin and inactivation of leutinizing hormone-releasing hormone (LHRH).
| Purity | ≥95% |
|---|---|
| Formula | C53H77N14O12 |
| Formula Wt. | 1102.29 |
| Synonym | ACE inhibitor peptide |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Martins AR, Caldo H, Coelho HL, et al. Screening for rabbit brain neuropeptide-metabolizing peptidases. Inhibition of endopeptidase B by bradykinin potentiating peptide 9a (SQ 20881). J Neurochem. 1980 Jan;34(1):100-7. PMID: 6161209.
Oparil S, Koerner T, O'Donoghue JK. Mechanism of angiotensin I converting enzyme inhibition by SQ20,881 (less than Glu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) in vivo. Further evidence for extrapulmonary conversion. Hypertension. 1979 Jan-Feb;1(1):13-22. PMID: 232489.
Vollmer RR, Boccagno JA, Harris DN, et al. Hypotension induced by inhibition of angiotensin-converting enzyme in pentobarbital-anesthetized dogs. Eur J Pharmacol. 1978 Sep 1;51(1):39-45. PMID: 212276.