• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Aprepitant

Aprepitant

Product ID A6368
Cas No. 170729-80-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $93.00 In stock
10 mg $121.70 In stock
25 mg $207.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aprepitant is an inhibitor of the tachykinin/neurokinin 1 (NK1) receptor that acts as an antiemetic or anti-nausea medicine. Aprepitant also exhibits some anticancer chemotherapeutic and anti-angiogenic benefit through its inhibition of NK1 receptors, preventing binding of substance P and inhibiting substance P’s proliferative and pro-angiogenic signaling cascade. This compound may also display some antidepressant activity, although in vivo and clinical results have been mixed.

Product Info

Cas No.

170729-80-3

Purity

≥98%

Formula

C23H21F7N4O3

Formula Wt.

534.43

Chemical Name

5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

IUPAC Name

5-[[(2R,3S)-2-[(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl] methyl]-1,2-dihydro-1,2,4-triazol-3-one

Synonym

(2R)-[(1R)-3,5-bis(trifluoromethyl)phenylethoxy]-(3S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methyl morpholine, Emend, L-754,030, MK-869, MK-0869, ONO-7436

Melting Point

255°C

Appearance

White to off white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A6368 MSDS PDF

Info Sheet

A6368 Info Sheet PDF

References

Muñoz M, Martinez-Armesto J, Coveñas R. NK-1 receptor antagonists as antitumor drugs: a survey of the literature from 2000 to 2011. Expert Opin Ther Pat. 2012 Jul;22(7):735-46. PMID: 22697287.

Massaro AM, Lenz KL. Aprepitant: a novel antiemetic for chemotherapy-induced nausea and vomiting. Ann Pharmacother. 2005 Jan;39(1):77-85. PMID: 15562136.

Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998 Sep 11;281(5383):1640-5. PMID: 9733503.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P0398

    Pazufloxacin Methanesulfonate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • E5240

    Leu-Enkephalin

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • S5746

    Solanesol

    All-trans nonaprenol isoprenoid, found in Solan...

    TLC≥95%
  • C1635

    Ceftazidime Hydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.

    ≥98%
  • A5202

    Anabasine Hydrochloride

    Alkaloid originally found in species of Nicotia...

    ≥98%
  • Q8134

    Quinapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • F3209

    Fibronectin-Binding Protein

    Peptide, binds fibronectin.

    ≥95%
  • E5201

    Enalapril Maleate

    ACE inhibitor.

    ≥98%
  • V1870

    Verruculogen

    Mycotoxin produced by Aspergillus; BK K+ channe...

    ≥95%
  • P0253

    Panaxadiol

    Triterpene sapongenin found in species of Panax...

    ≥98%
  • A1332

    Adipokinetic Hormone II from Locusta migratoria

    Neuropeptide found in Locusta migratoria.

    ≥98%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • N3213

    Nidulal

    Sesquiterpene found in Nidula.

    ≥95%
  • M1335

    Mdivi-1

    Quinazolinone; mitochondrial division inhibitor...

    ≥98%
  • S0245

    Salmeterol

    β2-adrenergic agonist.

    ≥98%
  • E9418

    Exendin 3 (9-39)

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only