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Aprepitant

Aprepitant

Product ID A6368
Cas No. 170729-80-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $93.00 In stock
10 mg $121.70 In stock
25 mg $207.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aprepitant is an inhibitor of the tachykinin/neurokinin 1 (NK1) receptor that acts as an antiemetic or anti-nausea medicine. Aprepitant also exhibits some anticancer chemotherapeutic and anti-angiogenic benefit through its inhibition of NK1 receptors, preventing binding of substance P and inhibiting substance P’s proliferative and pro-angiogenic signaling cascade. This compound may also display some antidepressant activity, although in vivo and clinical results have been mixed.

Product Info

Cas No.

170729-80-3

Purity

≥98%

Formula

C23H21F7N4O3

Formula Wt.

534.43

Chemical Name

5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

IUPAC Name

5-[[(2R,3S)-2-[(1R)-1-[3, 5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl] methyl]-1,2-dihydro-1,2,4-triazol-3-one

Synonym

(2R)-[(1R)-3,5-bis(trifluoromethyl)phenylethoxy]-(3S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methyl morpholine, Emend, L-754,030, MK-869, MK-0869, ONO-7436

Melting Point

255°C

Appearance

White to off white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A6368 MSDS PDF

Info Sheet

A6368 Info Sheet PDF

References

Muñoz M, Martinez-Armesto J, Coveñas R. NK-1 receptor antagonists as antitumor drugs: a survey of the literature from 2000 to 2011. Expert Opin Ther Pat. 2012 Jul;22(7):735-46. PMID: 22697287.

Massaro AM, Lenz KL. Aprepitant: a novel antiemetic for chemotherapy-induced nausea and vomiting. Ann Pharmacother. 2005 Jan;39(1):77-85. PMID: 15562136.

Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998 Sep 11;281(5383):1640-5. PMID: 9733503.

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