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Arenobufagin

Arenobufagin

Product ID A6818
Cas No. 464-74-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $92.00 In stock
5 mg $255.30 In stock
25 mg $918.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Arenobufagin is a bufanolide steroid found in the Argentine toad Bufo arenarum. This compound exhibits anticancer chemotherapeutic and anti-angiogenic properties, but is also cardiotoxic, inhibiting cardiovascular Na+/K+ pumps. In cellular models, arenobufagin induces autophagy and apoptosis, inhibiting tumor growth through indirect inhibition of the PI3K/Akt/mTOR signaling pathway. Arenobufagin also inhibits VEGFR2 directly through blockade of ATP-binding sites.

Product Info

Cas No.

464-74-4

Purity

≥98%

Formula

C24H32O6

Formula Wt.

416.51

IUPAC Name

5-[(3S,5R,8R,9S,10S,11S,13R,14S,17R)-3,11,14-trihydroxy-10, 13-dimethyl-12-oxo-2,3,4,5,6,7,8,9,11,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one

Solubility

10mM in DMSO

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6818 MSDS PDF

Info Sheet

A6818 Info Sheet PDF

References

Zhang DM, Liu JS, Deng LJ, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42. PMID: 23393227.

Li M, Wu S, Liu Z, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60. PMID: 22305746.

Cruz Jdos S, Matsuda H. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. PMID: 8223897.

Garraffo HM, Gros EG. Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. Steroids. 1986 Sep-Oct;48(3-4):251-7. PMID: 3127947.

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