LKT Labs

Biochemicals for Life Science Research

Artesunate

Artesunate

Product ID A6982
Cas No. 88495-63-0
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $61.10 In stock
100 mg $92.00 In stock
500 mg $153.10 In stock
1 g $224.60 In stock
Bulk Quote

Quicklinks

Description

Artesunate is a sesquiterpene lactone derived from Artemisia. Artesunate exhibits anticancer chemotherapeutic, antiviral, anti-angiogenic, and anti-parasitic activities. Artemisinins such as artesunate are best known for their antimalarial activity. Artesunate induces G0/G1 phase cell cycle arrest, increases levels of Bax and caspase 3, and decreases levels of Bcl-2, inhibiting tumor growth in animal models of breast cancer. In models of cervical cancer, artesunate inhibits production of prostaglandin E2 (PGE2) and decreases the number of Treg cells, also inhibiting tumor growth. Artesunate induces cell cycle arrest and inhibits replication of Polyoma virus as well. Additionally, this compound inhibits neovascularization and inflammation in corneas, increasing the Bax/Bcl-2 ratio and ROS levels, decreasing the mitochondrial membrane potential, and activating p38 MAPK.

Product Info

Cas No.

88495-63-0
Purity

≥98%
Formula

C19H28O8
Formula Wt.

384.42
Chemical Name

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]1,2-benzodioxepin-10-ol,hydrogen succinate
IUPAC Name

4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid
Synonym

Artesunic acid, Dihydroqinghaosu hemisuccinate, Arsumax, Plasmotrin, Qinghaozhi
Melting Point

132-135°C
Solubility

Slightly soluble in water.

Appearance

Odorless White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A6982 MSDS PDF
Info Sheet

A6982 Info Sheet PDF

References

Zhang LX, Liu ZN, Ye J, et al. Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression. Cell Biol Int. 2014 May;38(5):639-46. PMID: 24446394.

Dong HY, Wang ZF. Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts. Chin J Cancer Res. 2014 Apr;26(2):200-7. PMID: 24826061.

Sharma BN, Marschall M, Henriksen S, et al. Antiviral effects of artesunate on polyomavirus BK replication in primary human kidney cells. Antimicrob Agents Chemother. 2014 Jan;58(1):279-89. PMID: 24145549.

Cheng R, Li C, Li C, et al. The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells. Invest Ophthalmol Vis Sci. 2013 May 15;54(5):3400-9. PMID: 23611999.

Gomes TC, de Andrade Júnior HF, Lescano SA, et al. In vitro action of antiparasitic drugs, especially artesunate, against Toxoplasma gondii. Rev Soc Bras Med Trop. 2012 Jul-Aug;45(4):485-90. PMID: 22930046.

Haynes RK, Chan WC, Wong HN, et al. Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action. ChemMedChem. 2010 Aug 2;5(8):1282-99. PMID: 20629071.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D5747

    Dolasetron Mesylate Hydrate

    5-HT3 antagonist.

    ≥98%
  • C1844

    Celastrol

    Triterpene isolated Trypterigium wilfordii; HSP...

    ≥98%
  • S8246

    Sulfadimethoxine

    Sulfonamide; folic acid synthesis inhibitor.

    ≥98%
  • H9717

    Hydroxyzine Dihydrochloride

    FIASMA, histamine H1 inverse agonist, 5-HT2A, D1/2...
    ≥98%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • H9815

    25-Hydroxyvitamin D3

    Vitamin D, calcitriol prodrug; VDR agonist.

    ≥98%
  • A0967

    Adrenocorticotropic Hormone (1-17), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • G571344

    (±)-Goitrin

    Reduces production of thyroid hormones

    ≥98%
  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • C4535

    Clinafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • T1952

    Tenuazonic Acid Copper Salt

    Mycotoxin produced by Alternaria; photosynthesi...

    ≥98%
  • O783743

    OTSSP167 Hydrochloride

    MELK inhibitor.

    ≥98%
  • A7210

    L-(+)-Ascorbic Acid

    Form of vitamin C found in various plant and fo...

    ≥98%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • A7400

    ASP3026

    ALK inhibitor.

    ≥98%
  • N1868

    Neratinib

    EGFR inhibitor.

    ≥98%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • A744789

    ASTX660

    Antitumor

    ≥98%
  • G4580

    Glucosamine Hydrochloride

    Endogenous amino sugar precursor required for p...

    ≥96%