• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
ATB 346

ATB 346

Product ID A7604
Cas No. 1226895-20-0
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $52.50 In stock
5 mg $89.30 In stock
25 mg $252.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ATB346 is a hydrogen sulfide-releasing non-steroidal anti-inflammatory drug (NSAID) that inhibits COX and suppresses prostaglandin production. ATB346 exhibits anti-inflammatory, analgesic, antinociceptive, immunomodulatory, and neuroprotective activities. In vivo, this compound attenuates zymosan-induced inflammation, nociception, and immune signaling. ATB346 also prevents ligature-induced periodontal bone loss and pathologies, potentially by suppressing increases in pro-inflammatory cytokine levels. Additionally, ATB346 decreases edema and improves neurological function in animal models of traumatic brain injury (TBI). ATB346 is a hydrogen sulfide releasing derivative of naproxen.

Product Info

Cas No.

1226895-20-0

Purity

≥99%

Formula

C21H19NO3S

Formula Wt.

365.45

Chemical Name

4-Carbamothioylphenyl 2-(6-methoxy-2-naphthyl)propanoate

IUPAC Name

4-Carbamothioylphenyl 2-(6-methoxy-2-naphthyl)propanoate

Synonym

ATB-346

Solubility

DMSO: ≥ 52 mg/mL

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7604 MSDS PDF

Info Sheet

A7604 Info Sheet PDF

References

Dief AE, Mostafa DK, Sharara GM, et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci. 2015 Apr;19(8):1537-46. PMID: 25967731.

Herrera BS, Coimbra LS, da Silva AR, et al. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis. Med Gas Res. 2015 Feb 27;5:4. PMID: 25755876.

Campolo M, Esposito E, Ahmad A, et al. Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. J Neuroinflammation. 2014 Dec 4;11:196. PMID: 25472548.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S5868

    Sorafenib

    c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5...

    ≥98%
  • S0930

    Schisantherin A

    Dibenzocyclooctadiene found in Schisandra.

    ≥98%
  • H0142

    Haloperidol

    Butyrophenone; σ2 agonist, α1-adrenergic, D2,...

    ≥95%
  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibi...

    ≥95%
  • C3576

    Citreoviridin A

    Mycotoxin; F1F0 ATP synthase inhibitor.

    ≥95%
  • D0182

    Daunorubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • A9912

    AZD-7762 Hydrochloride

    CHK1 inhibitor.

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • D5994

    Doxepin Hydrochloride

    FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, hi...

    ≥98%
  • P0344

    Palbociclib Isethionate

    CDK4/6 inhibitor.

    ≥98%
  • U698576

    Urolithin B

    Ellagic acid derivative produced by gut microfl...

    ≥99%
  • S8046

    R-Sulforaphane, High Purity

    Naturally occuring isothiocyanate found in broc...

    ≥98%
  • A484091

    Amcinonide

    Glucocorticoid

    ≥98%
  • W0275

    R-(+)-Warfarin Sodium >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • C002041

    Cabazitaxel

    Taxoid that disrupts the microtubular network i...

    ≥98%
  • L5624

    Loganin

    Iridoid glucoside found in Cornus officialis; Î...

    ≥98%
  • S0244

    Salsalate

    Salicylic acid prodrug, NSAID; weak COX-1/2 inh...

    ≥95%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only