LKT Labs

Biochemicals for Life Science Research

Atorvastatin Calcium Trihydrate

Atorvastatin Calcium Trihydrate

Product ID A7658
Cas No. 344423-98-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
50 mg $207.50 In stock
100 mg $321.90 In stock
Bulk Quote

Quicklinks

Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

Product Info

Cas No.

344423-98-9
Purity

≥98%
Formula

(C33H34FN2O5)2Ca • 3H2O
Formula Wt.

1209.39
Chemical Name

(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid

IUPAC Name

calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate
Synonym

Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator
Melting Point

159-161°C

Solubility

Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml)
Appearance

Off White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A7658 MSDS PDF
Info Sheet

A7658 Info Sheet PDF

References

Cai J, Yu X, Zhang B, et al. Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury. Am J Nephrol. 2014;39(6):466-75. PMID: 24854145.

Akahori H, Tsujino T, Naito Y, et al. Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. J Hypertens. 2014 Jul;32(7):1534-41. PMID: 24759122.

Lea AP, McTavish D. Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47. PMID: 9129869.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1693

    Dexamethasone

    Glucocorticoid agonist.

    ≥99%
  • R1776

    Resveratrol

    Phenolic phytoalexin found in soy, grapes, and ...

    ≥99%
  • V3278

    Vitamin E Acetate

    Vitamin E analog, antioxidant.

    ≥98%
  • A1330

    Adipokinetic Hormone

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • SB5776

    Snake venom – Bothrops alternatus (urutu)

    Snake venom found in Bothrops alternatus urutu....

    ≥98%
  • R5745

    Rolipram

    Anxiolytic-like agent that stimulates angiogene...

    ≥98%
  • P3540

    PIK-75 Hydrochloride

    p110α PI3K inhibitor.

    ≥98%
  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • V5870

    Vortioxetine

    5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/...

    ≥99%
  • J8800

    JW55

    TNKS1/2 inhibitor.

    ≥98%
  • A2658

    Agomelatine

    Melatonin analog; MT1/2 agonist, 5-HT2C antagon...

    ≥98%
  • T5720

    Tofacitinib Citrate

    JAK1/2/3 inhibitor.

    ≥99%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • V5734

    Vorinostat

    HDAC inhibitor, RNA splicing inhibitor.

    ≥98%
  • E7731

    17-α-Ethynylestradiol

    Synthetic steroid hormone; ER agonist.

    ≥99%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • C0156

    9-Nitro-20S-camptothecin

    Camptothecin derivative; topoisomerase I inhibi...

    ≥98%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%