Atorvastatin Calcium Trihydrate

Name: Atorvastatin Calcium Trihydrate
SKU: A7658
Availability: InStock

Product ID A7658

Cas No. 344423-98-9

Purity ≥98%

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Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

Product Info

Cas No.	344423-98-9
Purity	≥98%
Formula	(C₃₃H₃₄FN₂O₅)₂Ca • 3H₂O
Formula Wt.	1209.39
Chemical Name	(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
IUPAC Name	calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate
Synonym	Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator
Melting Point	159-161°C
Solubility	Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml)
Appearance	Off White Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

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MSDS	A7658 MSDS PDF
Info Sheet	A7658 Info Sheet PDF

References

Cai J, Yu X, Zhang B, et al. Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury. Am J Nephrol. 2014;39(6):466-75. PMID: 24854145.

Akahori H, Tsujino T, Naito Y, et al. Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. J Hypertens. 2014 Jul;32(7):1534-41. PMID: 24759122.

Lea AP, McTavish D. Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47. PMID: 9129869.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

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Atorvastatin Calcium Trihydrate

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Description

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