Atorvastatin Calcium Trihydrate

Name: Atorvastatin Calcium Trihydrate
SKU: A7658
Availability: InStock

Product ID A7658

Cas No. 344423-98-9

Purity ≥98%

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Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

Product Info

Cas No.	344423-98-9
Purity	≥98%
Formula	(C₃₃H₃₄FN₂O₅)₂Ca • 3H₂O
Formula Wt.	1209.39
Chemical Name	(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
IUPAC Name	calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate
Synonym	Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator
Melting Point	159-161°C
Solubility	Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml)
Appearance	Off White Powder

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Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A7658 MSDS PDF
Info Sheet	A7658 Info Sheet PDF

References

Cai J, Yu X, Zhang B, et al. Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury. Am J Nephrol. 2014;39(6):466-75. PMID: 24854145.

Akahori H, Tsujino T, Naito Y, et al. Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. J Hypertens. 2014 Jul;32(7):1534-41. PMID: 24759122.

Lea AP, McTavish D. Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47. PMID: 9129869.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

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Atorvastatin Calcium Trihydrate

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Description

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