LKT Labs

Biochemicals for Life Science Research

Avibactam Sodium

Avibactam Sodium

Product ID A851322
Cas No. 1192491-61-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $116.00 In stock
25 mg $286.00 In stock
100 mg $818.00 In stock
Bulk Quote

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Description

Avibactam sodium is a diazabicyclooctane β-lactamase inhibitor. When avibactam is used in combination with ceftazidime, a β-lactam inhibitor, multidrug-resistant Gram-negative bacterial infections may be effectively treated. Avibactam has a potent activity against Class A and Class C and also some Class D β-lactamases, and is most often used to restore the activity of ceftazidime. However, bacteria may also develop resistance to new combinations over time, and various combinations have been investigated including avibactam paired with other antibacterials such as aztreonam or metronidazole.

Product Info

Cas No.

1192491-61-4
Purity

≥98%
Formula

C7H10N3NaO6S
Formula Wt.

287.22
Chemical Name

sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
IUPAC Name

sodium;[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate
Synonym

AVE-1330A, NXL104; Avibactam Sodium Salt
Solubility

Soluble in water (>140 mg/mL), DMSO (≥30mg/mL).

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A851322 MSDS PDF
Info Sheet

A851322 Info Sheet PDF

References

Frohlich C, Sorum V, Thomassen AM, et al. OXA-48-Mediated ceftazidime-avibactam resistance is associated with evolutionary trade-offs. mSphere. 2019 Mar 27;4(2):pii: e00024-19. PMID: 30918055.

Sanz-Garcia F, Hernando-Amado S, Martinez JL. Mutation-driven evolution of pseudomonas aeroginosa in the presence of either ceftazidime or ceftazidime-avibactam. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01379-18. PMID: 30082283.

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