• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AZ-628

AZ-628

Product ID A9662
Cas No. 878739-06-1
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $102.00 In stock
5 mg $377.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZ-628 is an irreversible Raf kinase inhibitor that exhibits anticancer chemotherapeutic activity in vitro and in vivo. AZ-628 strongly inhibits tumor cell growth in cells exhibiting mutant (V600E) B-Raf, a mutation commonly found in a variety of cancer subtypes; this compound also inhibits growth in several cell lines that were resistant to most other Raf inhibitors. AZ-628 exhibits similar inhibition of B-Raf and c-Raf in vitro but appears to be selective for B-Raf in vivo.

Product Info

Cas No.

878739-06-1

Purity

≥96%

Formula

C27H25N5O2

Formula Wt.

451.52

Chemical Name

3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide

IUPAC Name

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl) amino]phenyl]benzamide

Solubility

DMSO 90 mg/mL (199.32 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9662 MSDS PDF

Info Sheet

A9662 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Whittaker SR, Theurillat JP, Van Allen E, et al. A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Cancer Discov. 2013 Mar;3(3):350-62. PMID: 23288408.

Montagut C, Sharma SV, Shioda T, et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008 Jun 15;68(12):4853-61. PMID: 18559533.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A985120

    AZD-0156

    Inhibitor of ATM.

    ≥98%
  • T1673

    Terlipressin Acetate

    Synthetic peptide, vasopressin analog; AVPR1 ag...

    ≥95%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%
  • E5211

    Endomorphin-2

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • R0154

    Ranolazine Dihydrochloride

    Nav1.7 and Nav1.8 N1+ channel blocker.

    ≥98%
  • C5645

    Colchicine

    Found in Colchicum; microtubule polymerization ...

    ≥97%
  • Z0252

    Zanamivir

    Neuraminidase inhibitor.

    ≥98%
  • F4681

    Flumazenil

    GABA-A antagonist.

    ≥98%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%
  • P200002

    PF-07321332

    Inhibitor of coronaviruses

    ≥99%
  • C9773

    L-Cystine

    Endogenous amino acid, forms disulfide bridges ...

    ≥98%
  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • E325125

    EIDD-2801

    COVID-19 research

    ≥98%
  • E7209

    Escitalopram Oxalate

    S-enantiomer of citalopram; SERT inhibitor.

    ≥99%
  • U6859

    Urocortin III, human

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • M400005

    MK-5108 Hydrochloride

    Aurora kinase A inhibitor.

    ≥98%
  • V9202

    VX-702

    p38 MAPK inhibitor.

    ≥98%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • H5748

    D,L-Homocysteine Thiolactone Hydrochloride

    Heterocyclic derivative of cysteine, alters pro...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only