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AZD-4547

AZD-4547

Product ID A9814
Cas No. 1035270-39-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $114.80 In stock
10 mg $177.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-4547 is an inhibitor of FGFR that is somewhat selective for FGFR2 over FGFR1 and FGFR3; it exhibits anticancer chemotherapeutic activities. This compound is currently in clinical trials as a potential treatment for breast cancer. In breast cancer cells, AZD-4547 induces apoptosis and inhibits cellular proliferation, invasion and migration. In vivo, this compound inhibits tumor growth and metastasis.

Product Info

Cas No.

1035270-39-3

Purity

≥98%

Formula

C26H33N5O3

Formula Wt.

463.57

IUPAC Name

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide

Synonym

AZD-4547

Solubility

DMSO 92 mg/mL (198.45 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9814 MSDS PDF

Info Sheet

A9814 Info Sheet PDF

References

Liu L, Ye TH, Han YP, et al. Reductions in myeloid-derived suppressor cells and lung metastases using AZD4547 treatment of a metastatic murine breast tumor model. Cell Physiol Biochem. 2014;33(3):633-45. PMID: 24642893.

Zhang J, Zhang L, Su X, et al. Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res. 2012 Dec 15;18(24):6658-67. Erratum in: Clin Cancer Res. 2013 Jul 1;19(13):3714. Schöttle, Jakob [added]. PMID: 23082000.

Gavine PR, Mooney L, Kilgour E, et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012 Apr 15;72(8):2045-56. PMID: 22369928.

Custom Order

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