Description
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Product Unit Size | Cost | Quantity | Stock |
---|
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Cas No. | 602306-29-6 |
---|---|
Purity | ≥98% |
Formula | C18H21N5O2S |
Formula Wt. | 371.45 |
Chemical Name | 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine |
IUPAC Name | 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
Synonym | AZD5438; MMV676604 |
Solubility | Insoluble in water. Soluble in DMSO (>20 mg/mL). |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.
Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.
FLT3, PDGFR inhibitor.
CID-797718 analog; potential PKD1 binding agent...
ATP competitive CDK inhibitor.
Long chain acylcarnitine involved in fatty acid...
Somewhat selective in inhibiting COX-2 over COX...
Triterpenoid
Carotenoid terpene pigment found in various pla...
Histamine H1 antagonist.
Walrycin response regulator inhibitor.
HIV protease inhibitor, SERCA inhibitor.
Flavonoid originally found in Silybum (milk thi...
Synthetic steroid hormone, estrogen analog, use...
Endogenous cardiomodulatory peptide; NPR-A agon...
σ1 antagonist.
Ethisterone derivative, synthetic steroid, used...
Endogenous peptide, involved in stress signalin...
mAChR antaonist.
Endogenous amino acid, precursor of 5-HT and me...
NPC1L1 inhibitor.
Water-soluble cortisol derivative; glucocortico...