Description
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Product Unit Size | Cost | Quantity | Stock |
---|
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Cas No. | 602306-29-6 |
---|---|
Purity | ≥98% |
Formula | C18H21N5O2S |
Formula Wt. | 371.45 |
Chemical Name | 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine |
IUPAC Name | 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
Synonym | AZD5438; MMV676604 |
Solubility | Insoluble in water. Soluble in DMSO (>20 mg/mL). |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.
Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.
Endogenous peptide hormone derived from POMC, i...
N-acetyl cysteine conjugate of phenethylisothio...
Fluoroquinolone; bacterial DNA gyrase inhibitor...
Steroidal saponin found in Dioscorea.
Non-selective CB receptor agonist.
Pyrimidine nucleoside (cytidine) analog; DNA ch...
Captothecin derivative; topoisomerase I inhibit...
Vitamin A derivative; RAR and RXR agonist.
Naphthalene; indirect STAT1 agonist.
TRPC5, NS4B, histamine H1 inhibitor.
Macrolide; protein synthesis inhibitor. ≥3900...
Quinoid diterpene found in species of Salvia; S...
Naturally sourced ITC, sulfonyl analog of sulfo...
β-lactam cephalosporin; penicillin binding pro...
Aspartyl protease inhibitor.
Nitrogen mustard and estradiol derivative; micr...
Amphiphilic properties
Diketopiperazine produced by Aspergillus; micro...
Oxyindole alkaloid found in Uncaria sinensis; h...
BRD2/3/4 inhibitor.