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AZD-5438

AZD-5438

Product ID A965121
Cas No. 602306-29-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $382.90 In stock
100 mg $1,161.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.

Product Info

Cas No.

602306-29-6

Purity

≥98%

Formula

C18H21N5O2S

Formula Wt.

371.45

Chemical Name

4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine

IUPAC Name

4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine

Synonym

AZD5438; MMV676604

Solubility

Insoluble in water. Soluble in DMSO (>20 mg/mL).

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A965121 MSDS PDF

Info Sheet

A965121 Info Sheet PDF

References

Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.

Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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