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Bafilomycin A1

Bafilomycin A1

Product ID B0025
Cas No. 88899-55-2
Purity ≥90%
Product Unit SizeCostQuantityStock
0.1 mg $62.70 In stock
0.5 mg $210.30 In stock
1 mg $388.40 In stock
5 mg $1,342.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bafilomycin A1 is a macrolide antibiotic initially produced by Streptomyces that exhibits anti-parasitic, antimalarial, and anticancer chemotherapeutic activities. Bafilomycin A1 inhibits the vacuolar H+ ATPase and suppresses autophagy. Bafilomycin kills Plasmodium parasites in cellular models, and separately, induces cell death and suppresses tumor growth in animal models of breast cancer.

Product Info

Cas No.

88899-55-2

Purity

≥90%

Formula

C35H58O9

Formula Wt.

622.83

IUPAC Name

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2, 4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8- hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11, 13-tetraen-2-one

Solubility

Soluble in DMSO, ethanol and methanol.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B0025 MSDS PDF

Info Sheet

B0025 Info Sheet PDF

References

Graham RM, Thompson JW, Webster KA. Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis. Oncotarget. 2014 Mar 15;5(5):1162-73. PMID: 24811485.

Xu MY, Lee SY, Kang SS, et al. Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy. J Nat Prod. 2014 Feb 28;77(2):370-6. PMID: 24547878.

van Schalkwyk DA, Chan XW, Misiano P, et al. Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem Pharmacol. 2010 May 1;79(9):1291-9. PMID: 20067768.

Custom Order

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