• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Bedaquiline

Bedaquiline

Product ID B165122
Cas No. 843663-66-1
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $222.40 In stock
10 mg $390.60 In stock
25 mg $931.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bedaquiline is a diarylquinoline found to be useful in treating multidrug-resistant tuberculosis. In mouse models of TB, bedaquiline has significantly shortened the treatment regimen. A long-acting injectable formulation has been shown to have prolonged bactericidal activity.
Bedaquiline inhibits ATP-synthase, and at high concentrations leads to suppression of oxidative phosphorylation. In rat liver mitochondria, bedaquiline suppresses the formation of MPT pores, which typically accompanies the development of tuberculosis. Several analogues of bedaquiline that may improve its bioavailability are also in development.

Product Info

Cas No.

843663-66-1

Purity

≥99%

Formula

C32H31BrN2O2

Formula Wt.

555.5

Chemical Name

(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol

IUPAC Name

(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol

Synonym

BQ1; bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol; Sirturo; TMC207

Melting Point

183.9°C

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

B165122 MSDS PDF

Info Sheet

B165122 Info Sheet PDF

References

Sarathy J, Ganapathy U, Zimmerman M, et al. TBAJ-876, a 3,5-dialkoxypyridine analogue of bedaquiline, is active against mycobacterium abscessus. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02404-19. PMID: 31964791.

Xu J, Li SY, Almeida D, et al. Contribution of pretomanid to novel regimens containing bedaquiline with either linezolid or moxifloxacin and pyrazinamide in murine models of tuberculosis. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e00021-19. PMID: 30833432.

Kaushik A, Ammerman N, Tyagi S, et al. Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e00007-19. PMID: 30745396.

Belosludtsev K, Belosludtseva N, Talanov E, et al. Effect of bedaquilinr on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):288-297. PMID: 29920239.

Blaser A, Sutherland H, Tong A, et al. Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. Bioorg Med Chem. 2019 Apr 1;27(7):1283-1291. PMID: 30792104.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1770

    Meropenem Sodium Carbonate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • T7034

    Trimethoprim

    Dihydrofolate reductase inhibitor.

    ≥98%
  • C344761

    Citalopram Chloromethyl Quaternary Ammonium Chloride

    Citalopram analog

    ≥95%
  • B3203

    Biapenem

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • R4132

    RKI-1447

    ROCK1/2 inhibitor.

    ≥98%
  • N0062

    D,L-Naproxen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • C9876

    CYT-387

    JAK2 inhibitor.

    ≥98%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • T3461

    Tiplaxtinin

    PAI-1 inhibitor.

    ≥98%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • M3232

    Methylisoindigotin

    Indirubin derivative.

    ≥98%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • N3346

    Nilotinib

    Phenylamino pyridine; Abl, c-Kit, PDGFR, PP2A i...

    ≥99%
  • O1177

    n-Octyl-3,4-Dimethylcaffeate

    Methylated derivative of n-octyl-caffeate.

    ≥98%
  • C4535

    Clinafloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A0918

    N-Acetyl-L-Cysteine

    Cysteine derivative, antioxidant, ROS scavenger...

    ≥98%
  • L960006

    LY-2606368

    CHK1 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only