• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Benidipine Hydrochloride

Benidipine Hydrochloride

Product ID B1752
Cas No. 91599-74-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $47.30 In stock
25 mg $78.80 In stock
100 mg $183.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Benidipine is a long-lasting dihydropyridine calcium channel blocker. Its antihypertensive activity involves the inhibition of Ca(2+) influx through L-type voltage dependent calcium channels and the ability to restore endothelial function. It prevents lysoPC-induced caspase-3 activation through stimulation of NO release thereby exerts its anti-apoptosis action on endothelial cells. Benidipine increases the maximal activity of ERK1/2 but has no significant effect on p38 MAPK, decreases mitochondrial cytochrome c release, and reduces caspase-9 activation.

Benidipine was shown to have antioxidant effect in reducing hydroxyl radicals formation and PKC-dependent NO production. It inhibits [3H]thymidine incorporation into vascular smooth muscle cells (VSMCs), an indication of its anti-proliferative effects which may be useful for the treatment of restenosis following angioplasty and atherosclerosis damages.

Product Info

Cas No.

91599-74-5

Purity

≥98%

Formula

C28H31N3O6 ・HCl

Formula Wt.

542.03

Chemical Name

5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride

IUPAC Name

(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

Synonym

KW-3049

Solubility

DMSO Solubility: 8 mg/mL (14.75 mM)

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1752 MSDS PDF

Info Sheet

B1752 Info Sheet PDF

References

Matsubara M , Yao K, Hasegawa K. Benidipine, a dihydropyridine-calcium channel blocker, inhibits
lysophosphatidylcholine-induced endothelial injury via stimulation of nitric oxide release.Pharmacol Res. 2006 Jan;53(1):35-43. PMID: 16172001.

Wang N , Minatoguchi S, Chen XH, et al.
Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits. J Cardiovasc Pharmacol. 2004 Jun;43(6):747-57. PMID: 15167267.

Ide S , Kondoh M, Satoh H, Karasawa A. Anti-proliferative effects of benidipine hydrochloride in porcine cultured
vascular smooth muscle cells and in rats subjected to balloon catheterinduced endothelial denudation.Biol Pharm Bull. 1994 May;17(5):627-31. PMID: 7920421.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S336507

    Simufilam Dihydrochloride

    Unlikely to reverse Alzheimer’s

    ≥98%
  • T1677

    Tetracycline

    Polyketide; protein translation inhibitor, mamm...

    ≥90%
  • S8247

    Sulfasalazine

    Mesalazine derivative, sulfa drug; sepiapterin ...

    ≥98%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • F1745

    Felodipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • B6998

    Bryostatin 1

    Macrolide lactone found in Bugula; TLR4 activat...

    ≥98%
  • D0255

    Dantrolene Sodium Heptahydrate

    Hydantoin derivative; RyR antagonist, L-type Ca...

    ≥98%
  • D5607

    Dobutamine Hydrochloride

    β1-adrenergic agonist, β2- and α1-adrenergic...

    ≥98%
  • A0933

    Acitretin

    Retinoid; RARα/β/γ agonist.

    ≥98%, multiple isomers
  • M0278

    Matrine

    Alkaloid found in Sophora.

    ≥98%
  • C0249

    Calcitonin Gene Related Peptide (8-37), rat

    Endogenous calcitonin-family peptide frgament, ...

    ≥95%
  • H965142

    Hydrolyzed Fumonisin B1

    Mycotoxin produced by Fusarium fungi that infec...

    ≥99% by ELSD
  • R2815

    Recombinant HIV-1 “0” group consensus

    Recombinant HIV-1 antigen fragment.

    ≥95%
  • E6245

    Eplerenone

    Mineralocorticoid antagonist.

    ≥99%
  • C0265

    Carnosic Acid

    Diterpene found in Rosmarinus.

    ≥98%
  • E9201

    EX-527

    SIRT1 inhibitor.

    ≥99%
  • R8076

    Rutin Hydrate

    Flavonoid glycoside found in fruit, asparagus, ...

    ≥95%
  • N1989

    Neurotensin

    Endogenous neuropeptide involved in hormone rel...

    ≥95%
  • S0225

    SAG Dihydrochloride

    Smoothened agonist.

    ≥98%
  • C4557

    Clofibrate

    Fibrate; PPARα agonist.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only