LKT Labs

Biochemicals for Life Science Research

Bestatin Hydrochloride

Bestatin Hydrochloride

Product ID B1874
Cas No. 65391-42-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $100.20 In stock
10 mg $188.00 In stock
25 mg $357.30 In stock
Bulk Quote

Quicklinks

Description

Bestatin is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelocytic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.

65391-42-6
Purity

≥98%
Formula

C16H24N2O4 • HCl
Formula Wt.

344.87
Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine hydrochloride
IUPAC Name

(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Synonym

Ubenimex hydrochloride
Melting Point

216-218°C
Solubility

Soluble in water (25mg.mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B1874 MSDS PDF
Info Sheet

B1874 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • N582686

    L-(-)-Norepinephrine-(+)-bitartrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • B6959

    Bromosporine

    BRD2/4/9 and CECR2 inhibitor.

    ≥99%
  • A6828

    N(α),N(α)-Dimethyl-L-Arginine Ammonium

    Endogenous amino acid derivative, regulates water/...
    ≥98%
  • L0284

    Lavendustin A

    Tyrosine kinase inhibitor.

    ≥97%
  • S8005

    Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • E6257

    Epothilone B

    Microtubule depolymerization inhibitor.

    ≥98%
  • N800000

    NU-2058

    CDK1/2 inhibitor.

    ≥98%
  • T5720

    Tofacitinib Citrate

    JAK1/2/3 inhibitor.

    ≥99%
  • C4659

    Clobetasol Propionate

    Corticosteroid; glucocorticoid agonist.

    ≥98%
  • A4675

    Alternariol

    Mycotoxin produced by Alternaria; topoisomerase...

    ≥98%
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%
  • L283080

    LHC-165

    TLR7 agonist

    ≥99%
  • R6052

    Recombinant Mycoplasma Pneumonia Antigen

    Pneumonia antigen
  • I0416

    Iberin

    Isothiocyanate found in cruciferous vegetables,...

    ≥97%
  • P1852

    Penicillin G procaine

    Hydrophobic β-lactam; penicillin binding prote...

    ≥98%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%