LKT Labs

Biochemicals for Life Science Research

Bestatin Hydrochloride

Bestatin Hydrochloride

Product ID B1874
Cas No. 65391-42-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $100.20 In stock
10 mg $188.00 In stock
25 mg $357.30 In stock
Bulk Quote

Quicklinks

Description

Bestatin is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelocytic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.

65391-42-6
Purity

≥98%
Formula

C16H24N2O4 • HCl
Formula Wt.

344.87
Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine hydrochloride
IUPAC Name

(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Synonym

Ubenimex hydrochloride
Melting Point

216-218°C
Solubility

Soluble in water (25mg.mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B1874 MSDS PDF
Info Sheet

B1874 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0153

    Tanshinone I

    Diterpene found in Salvia.

    ≥95%
  • T0008

    Tacrolimus

    Calcineurin inhibitor.

    ≥98%
  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%
  • B3210

    R-Bicalutamide

    AR antagonist.

    ≥98%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • F465817

    Flunisolide

    Corticosteroid

    ≥90%
  • F4680

    Flutamide

    Non-steroid; AR antagonist.

    ≥98%
  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • E6997

    Erythropoietin, Human Recombinant

    Endogenous glycoprotein hormone involved in red...

    ≥97%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • K0040

    Kahweol Stearate

    Diterpene found in coffee beans.

    ≥98%
  • P0110

    (R)-P7C3-OMe

    Methoxy aminopropyl carbazole, neuroprotective....

    ≥98%
  • B6800

    Bradykinin Triacetate

    Natriuretic, vasodilatory peptide; B1/2 agonist...

    ≥95%
  • N1721

    Nefiracetam

    Pyrrolidone; NMDA and mGluR5 agonist, N-type an...

    ≥98%
  • D324094

    Diclofenac Related Compound A

    Impurity of diclofenac

    ≥98%
  • I0800

    IC-87114

    p110δ PI3K inhibitor.

    ≥98%
  • B1996

    BEZ235

    PI3K and mTOR inhibitor.

    ≥98%
  • S0500

    SB-203580

    p38 MAPK inhibitor.

    ≥98%
  • A5030

    4-Aminophenylphosphate Monosodium

    Alkaline phosphatase substrate used to quantify...

    ≥97%