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Bisacodyl

Bisacodyl

Product ID B3374
Cas No. 603-50-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $52.00 In stock
10 g $102.00 In stock
25 g $173.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bisacodyl is a diphenylmethane derivative that exhibits gastrointestinal motility modulating (laxative) activity. Bisacodyl activates macrophages, activating PKC, increasing PGE2 secretion, and downregulating expression of aquaporin 3 channels; it may also inhibit the Na+/K+ ATPase. As a result of these actions, colonic fluid and NaCl secretion is increased. Bisacodyl also stimulates enteric nerves, increasing contractions.

Product Info

Cas No.

603-50-9

Purity

≥98%

Formula

C22H19NO4

Formula Wt.

361.39

Chemical Name

4,4'-(2-Pyridylmethylene)-bisphenol diacetate

IUPAC Name

[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate

Synonym

Bicol, Broxalax, Contalax, DAMP, Dulrolax, Endokolat, Laxadin, Laxorex, Perilax, Telemin, Ulcolax

Melting Point

138°C

Solubility

Soluble in acids, acetone, propylene glycol and other organic solvents. Ethanol (4.5 mg/mL). Practically insoluble in water and alkaline solutions.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

B3374 MSDS PDF

Info Sheet

B3374 Info Sheet PDF

References

Ikarashi N, Baba K, Ushiki T, et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G887-95.PMID: 21868635.

Manabe N, Cremonini F, Camilleri M, et al. Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther. 2009 Nov 1;30(9):930-6. PMID: 19678812.

Beubler E, Schirgi-Degen A. Stimulation of enterocyte protein kinase C by laxatives in-vitro. J Pharm Pharmacol. 1993 Jan;45(1):59-62. PMID: 8094448.

Custom Order

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