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Brassinin

Brassinin

Product ID B6801
Cas No. 105748-59-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $88.60 In stock
50 mg $216.40 In stock
100 mg $346.60 In stock
250 mg $721.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Brassinin is a phytoalexin originally found in cruciferous vegetables. This indole exhibits anticancer chemotherapeutic and chemopreventive activities. In prostate cancer cells, brassinin induces G1 phase cell cycle arrest and apoptosis, decreases the mitochondrial membrane potential, suppresses caspase 3 and PARP activation, and limits PI3K/Akt/mTOR signaling. In vivo, brassinin inhibits indoleamine 2,3-dioxygenase, inducing regression of mammary gland tumors. In other animal models, this compound inhibits DMBA-induced skin tumor formation. Like other compounds produced by cruciferous vegetables, brassinin may induce phase II enzymes, displaying potential antioxidative benefit.

Product Info

Cas No.

105748-59-2

Purity

≥98%

Formula

C11H12N2S2

Formula Wt.

236.36

Chemical Name

methyl (1H-indol-3-ylmethylamino)methanedithioate

IUPAC Name

methyl N-(1H-indol-3-ylmethyl)carbamodithioate

Synonym

methyl N-(1H-indol-3-ylmethyl)-carbamodithioate

Melting Point

132-133°C

Solubility

Soluble in DMSO.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B6801 MSDS PDF

Info Sheet

B6801 Info Sheet PDF

References

Kim SM, Park JH, Kim KD, et al. Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Phytother Res. 2014 Mar;28(3):423-31. PMID: 23686889.

Banerjee T, Duhadaway JB, Gaspari P, et al. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7. PMID: 18026137.

Mehta RG, Liu J, Constantinou A, et al. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis. 1995 Feb;16(2):399-404. PMID: 7859373.

Custom Order

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