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Bromhexine is a synthetic derivative of vasicine that exhibits mucolytic and antioxidative activities. Bromhexine increases production of serous mucus, decreases mucus viscosity, and helps cilia transport mucus out of the lungs. Bromhexine is clinically used to treat respiratory disorders characterized by excessive mucus. Additionally, bromhexine also decreases production of ROS in alveolar macrophages by modulating enzymatic activity.
| Cas No. | 611-75-6 |
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| Purity | ≥98% |
| Formula | C14H20Br2N2 HCl |
| Formula Wt. | 412.60 |
| Chemical Name | 2-Amino-3,5-dibromo-N-cyclohexyl-N-methyl- benzenemethanamine hydrochloride |
| IUPAC Name | 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride |
| Synonym | Auxit, Bisolvon, Ophtosol, Quentan |
| Melting Point | 240-244°C |
| Solubility | Slightly soluble in chloroform. Sparingly soluble in ethanol or methanol. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Winsel K, Grollmuss H, Unger U, et al. Modulation of alveolar macrophage activity by ambroxol, bromhexine and exogenous arachidonic acid. Z Erkr Atmungsorgane. 1985;165(2):149-62. PMID: 3002048.
Takeda H, Abe Y, Misawa M, et al. The role of vagal reflex in mechanism of secretagogic action of bromhexine. Jpn J Pharmacol. 1984 Aug;35(4):445-50. PMID: 6503040.