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Bryostatin 1

Bryostatin 1

Product ID B6998
Cas No. 83314-01-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 µg $480.70 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bryostatin 1 is a macrolide lactone found in Bugula that exhibits neuroprotective, cognition enhancing, immunomodulatory, and anticancer chemotherapeutic activities. Bryostatin 1 activates PKC when administered acutely or in low doses and inhibits PKC when administered chronically or in high doses. Bryostatin 1 is currently in clinical trials as a co-administered chemotherapeutic in the treatment of various types of cancer. In animal models, this compound increases memory acquisition and storage. Additionally, bryostatin 1 activates PKD and decreases expression of β-catenin in vitro. In cellular models of Alzheimer’s disease, bryostatin 1 activates APP processing by α-secretase, decreasing levels of amyloid-β (Aβ). Bryostatin 1 improves MHC class II antigen presentation by CD4+ T cells in cellular models of Burkitt’s lymphoma and also activates toll-like receptor 4 (TLR4), inducing release of Th2 cytokines.

Product Info

Cas No.

83314-01-6

Purity

≥98%

Formula

C47H68O17

Formula Wt.

905.03

IUPAC Name

[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate

Melting Point

230-235°C

Solubility

Soluble in DMSO or ethanol.

Appearance

Colorless Film or White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B6998 MSDS PDF

Info Sheet

B6998 Info Sheet PDF

References

Irie K, Yanagita RC. Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin. Chem Rec. 2014 Apr;14(2):251-67. PMID: 24677503.

Yi P, Schrott L, Castor TP, et al. Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells. J Mol Neurosci. 2012 Sep;48(1):234-44. PMID: 22700373.

Hossain A, God JM, Radwan FF, et al. HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition. Clin Dev Immunol. 2011;2011:780839. PMID: 22162713.

Ariza ME, Ramakrishnan R, Singh NP, et al. Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cells. J Biol Chem. 2011 Jan 7;286(1):24-34. PMID: 21036898.

Jaggi M, Chauhan SC, Du C, et al. Bryostatin 1 modulates beta-catenin subcellular localization and transcription activity through protein kinase D1 activation. Mol Cancer Ther. 2008 Sep;7(9):2703-12. Erratum in: Mol Cancer Ther. 2009 May;8(5):1398. PMID: 18765827.

Kuzirian AM, Epstein HT, Gagliardi CJ, et al. Bryostatin enhancement of memory in Hermissenda. Biol Bull. 2006 Jun;210(3):201-14. PMID: 16801495.

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