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Butein

Butein

Product ID B8277
Cas No. 487-52-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $105.30 In stock
5 mg $188.00 In stock
10 mg $315.40 In stock
25 mg $578.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Butein is a flavonoid originally found in the bark of Rhus verniciflua and the flowers of Butea monosperma. Butein exhibits anticancer chemotherapeutic, anti-angiogenic, neuroprotective, anti-inflammatory, antioxidative, and anti-fibrotic activities. In lung cancer cells, butein decreases expression of COX-2, inducing cell cycle arrest and apoptosis; this compound also inhibits tumor growth of prostate cancer xenografts in vivo. Butein inhibits phosphorylation of Akt, mTOR, and their downstream targets and suppresses VEGF-induced cell proliferation, migration, and tube formation in endothelial progenitor cells; it also inhibits vessel sprouting from aortic rings in vivo. In animal models of spinal cord injury, butein decreases expression of NF-κB and IκBα, inhibits activation of caspase 3, and suppresses infiltration of neutrophils. In cellular models, this compound increases levels of glutathione and activity of catalase and glutathione S-transferase and decreases levels of lactate dehydrogenase. Butein also acts as a free radical scavenger. Additionally, butein prevents hepatic stellate cell (HSC) activation, downregulating expression of TGF-β, TIMP-1/2, and MMP-2 and inhibiting activation of NF-κB, p38, JNK, and Smad3.

Product Info

Cas No.

487-52-5

Purity

≥99%

Formula

C15H12O5

Formula Wt.

272.25

Chemical Name

2',3,4,4'-Tetrahydroxychalcone

IUPAC Name

(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

Synonym

2',3,4,4'-Tetrahydroxychalcone

Solubility

DMSO: ≥ 35 mg/mL

Appearance

Yellow-orange crystal powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B8277 MSDS PDF

Info Sheet

B8277 Info Sheet PDF

References

Li Y, Ma C, Qian M, et al. Butein induces cell apoptosis and inhibition of cyclooxygenase 2 expression in A549 lung cancer cells. Mol Med Rep. 2014 Feb;9(2):763-7. PMID: 24337484.

Chung CH, Chang CH, Chen SS, et al. Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:943187. PMID: 23840271.

Lu M, Wang S, Han X, et al. Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. Neurosci Lett. 2013 May 10;542:87-91. PMID: 23499960.

Szuster-Ciesielska A, Mizerska-Dudka M, Daniluk J, et al. Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress. J Gastroenterol. 2013 Feb;48(2):222-37. PMID: 22722906.

Sehrawat A, Kumar V. Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma. Biocell. 2012 Aug;36(2):63-71. PMID: 23185781.

Khan N, Adhami VM, Afaq F, et al. Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. Antioxid Redox Signal. 2012 Jun 1;16(11):1195-204. PMID: 22114764.

Custom Order

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