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C-Type Natriuretic Peptide (1-22), human

C-Type Natriuretic Peptide (1-22), human

Product ID C7997
Cas No. 127869-51-6
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $147.00 In stock
1 mg $262.50 In stock
2.5 mg $472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

C-type natriuretic peptide (CNP) is a natriuretic peptide (NP) that binds NP-B receptors. This peptide exhibits cardioprotective and anti-inflammatory activities. In animal models, CNP increases conduction velocity in the sinoatrial node and decreases infarct size in models of ischemia/reperfusion. In vitro, CNP decreases basal ATP-sensitive K+ channel openings and currents. Animal models of mutant CNP display arthritis, cartilage damage, and growth delay, highlighting roles for CNP in the regulation of skeletal growth and inflammation. CNP binding NP receptors increases cGMP levels and opens cystic fibrosis transmembrane receptor (CTFR) Cl- channels in a PDE3/cAMP/PKA-dependent manner.

Product Info

Cas No.

127869-51-6

Purity

≥95%

Formula

C93H157N27O28S3

Formula Wt.

2197.64

Synonym

CNP

Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C7997 MSDS PDF

Info Sheet

C7997 Info Sheet PDF

References

Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

Azer J, Hua R, Krishnaswamy PS, et al. Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart. J Physiol. 2014 Mar 1;592(Pt 5):1025-45. PMID: 24344164.

De Jonge HR, Tilly BC, Hogema BM, et al. cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland. Am J Physiol Cell Physiol. 2014 Feb;306(4):C343-53. PMID: 24259420.

Bükülmez H, Khan F, Bartels CF, et al. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis. Arthritis Rheumatol. 2014 Jan;66(1):78-89. PMID: 24449577.

Custom Order

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