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Calcitonin gene-related peptide (CGRP) (8-37) inhibits the CGRP receptor and is used in research studies to examine the effects of CGRP. CGRP (8-37) inhibits the effects of ghrelin and induces caspase 3-mediated apoptosis in retinal cells of animal models of coronary artery occlusion. Like CGRP, this fragment likely binds RAMP1 and CGRP receptors.
| Cas No. | 119911-68-1 |
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| Purity | ≥95% |
| Formula | C139H230N44O38 |
| Formula Wt. | 3125.65 |
| IUPAC Name | L-Valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanylglycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-serylglycylglycyl-L-valyl-L-valyl-L-lysyl-L-asparaginyl-L-asparaginyl-L-phenylalanyl-L-valyl-L-pro lyl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-lysyl-L-alanyl-L-phenylalaninamide |
| Synonym | CGRP (8-37) |
| Solubility | Soluble in water (0.5 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nguyen VT, Wu Y, Guillory AN, et al. Delta-opioid augments cardiac contraction through β-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan;33(1):77-82. PMID: 22108711.
Yang JH, Zhang YQ, Guo Z. Endogenous CGRP protects retinal cells against stress induced apoptosis in rats. Neurosci Lett. 2011 Aug 26;501(2):83-5. PMID: 21763400.