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Calcitonin gene-related peptide II (CGRP II) exhibits vasodilatory and gastrointestinal modulatory activities; it also appears to be associated with inflammation in diseases such as gout and rheumatoid arthritis. CGRP II dilates arterioles in vitro and inhibits pentagastrin-stimulated gastric acid secretion in clinical settings. Like CGRP, this peptide likely binds RAMP1 and CGRP receptors.
| Purity | ≥95% |
|---|---|
| Formula | C163H267N51O50S2 |
| Formula Wt. | 3805.39 |
| Synonym | CGRP II, rat, β-CGRP, rat |
| Solubility | Soluble in water (0.8 mg/mL). |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Vanner S. Mechanism of action of capsaicin on submucosal arterioles in the guinea pig ileum. Am J Physiol. 1993 Jul;265(1 Pt 1):G51-5. PMID: 8338172.
Hernanz A, De Miguel E, Romera N, et al. Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease. Br J Rheumatol. 1993 Jan;32(1):31-5. PMID: 7678534.
Beglinger C, Born W, Hildebrand P, et al. Calcitonin gene-related peptides I and II and calcitonin: distinct effects on gastric acid secretion in humans. Gastroenterology. 1988 Oct;95(4):958-65. PMID: 2900791.
