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Calcitonin, human

Calcitonin, human

Product ID C0148
Cas No. 21215-62-3
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $298.50 In stock
1 mg $537.30 In stock
2.5 mg $778.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Calcitonin is an endogenous neuropeptide that exhibits pro-oncogenic, anti-osteoarthritic, and anti-resorptive activities. Calcitonin induces activation of NF-κB, upregulating expression and activity of fibronectin, MMP-1, MMP-2, and MMP-9 and increasing cell growth in osteosarcoma cells. When administered clinically, calcitonin increases serum NO and urinary CTX-II levels, improving medial femoral condyle osteoarthritis. Calcitonin also inhibits SCDP-induced apoptosis of osteoclasts and increases bone formation and volume.

Product Info

Cas No.

21215-62-3

Purity

≥95%

Formula

C145H240N44O48S2

Formula Wt.

3417.88

Chemical Name

H-Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr- Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2

Synonym

Calcitonin M, human C carcinoma, hCT, Thyrocalcitonin

Solubility

Soluble in 5% acetic acid.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0148 MSDS PDF

Info Sheet

C0148 Info Sheet PDF

References

Tsagaraki I, Phenekos C, Tsilibary E, et al. Calcitonin-induced NF-κB activation up-regulates fibronectin expression in MG63 osteosarcoma cells. Anticancer Res. 2013 Nov;33(11):4901-6. PMID: 24222127.

Armagan O, Serin DK, Calisir C, et al. Inhalation therapy of calcitonin relieves osteoarthritis of the knee. J Korean Med Sci. 2012 Nov;27(11):1405-10. PMID: 23166425.

Kuo YJ, Tsuang FY, Sun JS, et al. Calcitonin inhibits SDCP-induced osteoclast apoptosis and increases its efficacy in a rat model of osteoporosis. PLoS One. 2012;7(7):e40272. PMID: 22792258.

Custom Order

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