Description
Calcium folinate is commonly co-administered with methotrexate or other similar chemotherapeutics to provide a folate source for some dividing cells, such as bone marrow cells. Calcium folinate may inhibit thymidylate synthase.
Calcium Folinate Pentahydrate
Product ID C0147
Cas No. 6035-45-6
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 6035-45-6 |
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| Purity | ≥95% |
| Formula | C20H21CaN7O7 5H2O |
| Formula Wt. | 601.59 |
| Chemical Name | N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4- oxo-6-pteridinyl)methyl]-amino]benzoyl]-L-glutamic acid calcium salt pentahydrate |
| IUPAC Name | calcium;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate |
| Synonym | Leucovorin, 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt |
| Melting Point | 240-250°C |
| Solubility | Soluble in water. Insoluble in ethanol. |
| Appearance | Pale yellow powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Chen C, Tian L, Zhang M, et al. Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice. Dig Dis Sci. 2013 Nov;58(11):3134-43. PMID: 23979434.
Payet B, Fabre G, Tubiana N, et al. Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography. Cancer Chemother Pharmacol. 1987;19(4):319-25. PMID: 3496173.