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Capsaicin, natural

Capsaicin, natural

Product ID C0266
Cas No. 404-86-4
Purity ≥95%, capsaicinoids content
Product Unit SizeCostQuantityStock
100 mg $61.10 In stock
250 mg $85.90 In stock
1 g $255.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Capsaicin is an agonist of transient receptor potential vanilloid (TRPV) channels that was originally found in peppers of the Capsicum genus. Capsaicin exhibits analgesic, anti-inflammatory, anti-obesity, and anticancer chemotherapeutic activity. Capsaicin also displays bronchoconstrictive activity and is used as a natural irritant. In vivo, this compound desensitizes TRPV1 channels, inhibiting thermal and mechanical hyperalgesia. In other animal models, capsaicin inhibits adipogenesis, decreases metabolic dysregulation, activates PPARα, and suppresses weight gain and fat deposition. Capsaicin also induces apoptosis via ROS and disruption of the mitochondrial membrane and inhibits tumor growth in cellular and animal models of prostate cancer, breast cancer, pancreatic cancer, and hepatocellular carcinoma.

This mixture contains capsaicin, ≥65%, dihydrocapsaicin, ~20%, and nordihydrocapsaicin, ~4 %.

Product Info

Cas No.

404-86-4

Purity

≥95%, capsaicinoids content

Formula

C18H27NO3

Formula Wt.

305.41

Chemical Name

(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8- methyl-6-nonenamide

IUPAC Name

(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

Synonym

Axsain, Mioton, Zacin, Zostrix

Melting Point

65°C

Solubility

Soluble in ether, benzene, and chloroform. Practically insoluble in cold water.

Appearance

Slight yellowish-white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C0266 MSDS PDF

Info Sheet

C0266 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Deng R, Yu S, Ruan X, et al. Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder. Cell Commun Signal. 2023 Dec 21;21(1):364. PMID: 38129926.

Díaz-Laviada I, Rodríguez-Henche N. The potential antitumor effects of capsaicin. Prog Drug Res. 2014;68:181-208. PMID: 24941670.

Leung FW. Capsaicin as an anti-obesity drug. Prog Drug Res. 2014;68:171-9. PMID: 24941669.

Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg. 2008 Jul;107(1):271-81. PMID: 18635498.

Jensen PG, Curtis PD, Dunn JA, et al. Field evaluation of capsaicin as a rodent aversion agent for poultry feed. Pest Manag Sci. 2003 Sep;59(9):1007-15. PMID: 12974352.

Custom Order

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