LKT Labs

Biochemicals for Life Science Research

Carbamazepine

Product ID C0270
Cas No. 298-46-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $32.20 In stock
5 g $66.90 In stock
25 g $213.90 In stock
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Description

Carbamazepine is an antiepileptic/anticonvulsant that also exhibits antipsychotic and anti-inflammatory activities. Carbamazepine inhibits voltage-gated Na+ channels, stabilizing the inactive conformation of the channel. Carbamazepine also potentiates GABA receptor signaling and inhibits ATP-sensitive K+ channels. Carbamazepine is clinically used to treat epilepsy, bipolar disorder, neuralgia/neuropathic pain, ADHD, schizophrenia, and post-traumatic stress disorder (PTSD). In animal models, carbamazepine decreases LPS-induced expression of TNF-α and IL-1β.

Product Info

Cas No.

298-46-4
Purity

≥98%
Formula

C15H12N2O
Formula Wt.

236.27
Chemical Name

5H-Dibenz[b,f]azepine-5-carboxamide
IUPAC Name

benzo[b][1]benzazepine-11-carboxamide
Synonym

Biston, Carbatrol, Epitol, Sirtal, Telesmin, Timonil
Melting Point

190-193°C
Solubility

Soluble in alcohol, acetone or propylene glycol. Practically insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C0270 MSDS PDF
Info Sheet

C0270 Info Sheet PDF

References

Gómez CD, Buijs RM, Sitges M. The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus. J Neurochem. 2014 Jun 5. [Epub ahead of print]. PMID: 24903676.

Zhou Q, Chen PC, Devaraneni PK, et al. Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin). 2014 May 21;8(4). [Epub ahead of print]. PMID: 24849284.

Rahman W, Dickenson AH. Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain. Neurosci Lett. 2013 Dec 17;557 Pt A:19-26. PMID: 23941888.

Bialer M. Why are antiepileptic drugs used for nonepileptic conditions? Epilepsia. 2012 Dec;53 Suppl 7:26-33. PMID: 23153207.

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