LKT Labs

Biochemicals for Life Science Research

Catharanthine base

Catharanthine base

Product ID C0376
Cas No. 2468-21-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $54.60 In stock
25 mg $102.30 In stock
100 mg $170.40 In stock
500 mg $306.70 In stock
Bulk Quote

Quicklinks

Description

Catharanthine is an alkaloid found in Catharanthus that is a chemical precursor in the synthesis of vinca alkaloids such as vinblastine and vincristine. Catharanthine displays weak anti-mitotic activity, binding tubulin poorly. Catharanthine exhibits anti-parasitic, vasodilatory, and antihypertensive activities. This compound shows antimalarial benefit against species of Plasmodium. In vivo, catharanthine inhibits voltage-gated Ca2+ channel currents, decreasing blood pressure and heart rate.

Product Info

Cas No.

2468-21-5
Purity

≥98%
Formula

C21H24N2O2
Formula Wt.

336.43
IUPAC Name

methyl (1R,15R,18R)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8,16-pentaene-1-carboxylate
Melting Point

138-140°C
Appearance

Almost White Crystalline Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C0376 MSDS PDF
Info Sheet

C0376 Info Sheet PDF

References

Munigunti R, Becker K, Brun R, et al. Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Nat Prod Commun. 2013 Aug;8(8):1135-6. PMID: 24079187.

Jadhav A, Liang W, Papageorgiou PC, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. PMID: 23532933.

Sertel S, Fu Y, Zu Y, et al. Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochem Pharmacol. 2011 Mar 15;81(6):723-35. PMID: 21219884.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7858

    Etoricoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • C4659

    Clobetasol Propionate

    Corticosteroid; glucocorticoid agonist.

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥96%
  • N3378

    S-Nitrosoglutathione

    NO donor.

    ≥95%
  • F4782

    Fludarabine Phosphate

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • D0353

    Danofloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A044176

    Abemaciclib

    CDK inhibitor.

    ≥98%
  • S0459

    SB-590885

    B-Raf inhibitor.

    ≥97%
  • P3469

    Pirfenidone

    Collagen synthesis inhibitor.

    ≥98%
  • G1209

    GDC-0980

    PI3K and mTOR inhibitor.

    ≥98%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • V3277

    Vitamin E

    Synthetic vitamin E, antioxidant.

    ≥98%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • T8269

    (S)-ar-Turmerone

    Sesquiterpene found in Curcuma.

    ≥97%
  • B0133

    Baicalin

    Flavone found in Scutellaria; prolyl oligopepti...

    ≥95%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • E7309

    Esculetin

    Coumarin lactone found in chicory and other pla...

    ≥99%
  • L1983

    Leucomyosuppressin

    Peptide found in insects.

    ≥95%
  • C864760

    CVT-313

    Selective CDK2 inhibitor.

    ≥98%
  • E5222

    Endothelin-3, human

    Endogenous peptide, involved in vascular contra...

    ≥95%