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Cefotaxime is a third generation β-lactam cephalosporin antibiotic. Cefotaxime exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefotaxime is also mostly resistant to β-lactamase activity.
| Cas No. | 64485-93-4 |
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| Purity | ≥96% |
| Formula | C16H16N5O7S2Na |
| Formula Wt. | 477.45 |
| Chemical Name | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-(2-amino-4- thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt |
| IUPAC Name | sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4. 2.0]oct-2-ene-2-carboxylate |
| Synonym | Cefotaxim sodium salt, Cefotax, Claforan, Pretor, Tolycar |
| Melting Point | 162-163 °C (dec) |
| Solubility | Soluble in water. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Philpott-Howard J, Williams JD. Activity of cephalosporin antibiotics against Haemophilus influenzae. Scand J Infect Dis Suppl. 1983;39:109-11. PMID: 6606223.
LeFrock JL, Prince RA, Leff RD. Mechanism of action, antimicrobial activity, pharmacology, adverse effects, and clinical efficacy of cefotaxime. Pharmacotherapy. 1982 Jul-Aug;2(4):174-84. PMID: 6302641.