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Celecoxib

Celecoxib

Product ID C1644
Cas No. 169590-42-5
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $118.40 In stock
500 mg $248.20 In stock
1 g $381.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2; it exhibits anti-inflammatory, analgesic, anticancer, and anti-metastatic activities. Celecoxib is clinically used to treat arthritis, acute pain, and ankylosing spondylitis. In hepatoma cells, celecoxib decreases the mitochondrial membrane potential, increases cytochrome c release, activates caspases 3 and 9, alters Bcl-2 and Bax levels, and induces apoptosis. In vitro, celecoxib inhibits release of IL-6, IL-1β, and MIP-1α, suppresses phosphorylation of JNK, and activates SIRT1. Additionally, this compound inhibits invasion and migration of nasopharyngeal carcinoma cells by decreasing activity of matrix metalloproteinases 2 and 9 (MMP2/9).

Product Info

Cas No.

169590-42-5

Purity

≥99%

Formula

C17H14F3N3O2S

Formula Wt.

381.37

Chemical Name

4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide

IUPAC Name

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

Synonym

SC-58635, Celebrex

Melting Point

157-159°C

Solubility

Insoluble in water. Soluble in DMSO (200 mg/mL), ethanol (100 mg/mL).

Appearance

White-cream to white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C1644 MSDS PDF

Info Sheet

C1644 Info Sheet PDF

References

Shao D, Kan M, Qiao P, et al. Celecoxib induces apoptosis via a mitochondria dependent pathway in the H22 mouse hepatoma cell line. Mol Med Rep. 2014 Oct;10(4):2093-8. PMID: 25109418.

Annamanedi M, Kalle AM. Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS One. 2014 Jun 20;9(6):e99285. PMID: 24950067.

Li WW, Long GX, Liu DB, et al. Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity. Pharmazie. 2014 Feb;69(2):132-7. PMID: 24640603.

Shi S, Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol. 2008 Mar;64(3):233-52. PMID: 17999057.

Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011 Mar;4(3):329-346. PMID: 21372033.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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