Description
CEP-28122 is an ALK inhibitor. It inhibits tumor growth in ALK positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroglastoma cells.
| Product Unit Size | Cost | Quantity | Stock |
|---|
CEP-28122 is an ALK inhibitor. It inhibits tumor growth in ALK positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroglastoma cells.
| Cas No. | 1354545-57-5 |
|---|---|
| Purity | ≥98% |
| Formula | C28H35ClN6O3 • CH4O3S |
| Formula Wt. | 635.18 |
| IUPAC Name | (1S,2S,3R,4R)-3-[(5-Chloro-2-{[(7S)-1-methoxy-7-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino}-4-pyrimidinyl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide methanesulfonate (1:1) |
| Synonym | CEP 28122 Mesylate, CEP28122 Mesylate |
| Solubility | 10 mM in DMSO |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Cheng M., Quail M., et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 11(3):670-79 (2012). PMID: 22203728.
Non-nitrogen bisphosphonate; mitochondrial ATP/...
Anthraquinone found in various plant sources; C...
Peptide, used as control to measure RGDS peptid...
ITC, erucin analog.
Endogenous opioid peptide; δOR and μOR agonis...
Carcinoembryonic antigen epitope analog.
Non-steroid; AR antagonist.
Endogenous peptide, involved in stress signalin...
Phallotoxin found in Amanita phalloides; microt...
Mast cell destabilizer; potential TRP antagonis...
H+/K+ ATPase and Scpc phosphatase inhibitor.
Endogenous organosulfur also found in meat and ...
Peptide, cleavage product of proenkephalin; κO...
Microtubule depolymerization inhibitor.
Found in Aristolochia and Radix; potential PLA2...
Non-endogenous essential vitamin (B9), found in...
Non-selective cannabinoid receptor agonist.
Histamine H2 antagonist.
Glutathione-ITC conjugate, antioxidant.
Effective against gram-positive pathogens