Description
CEP-28122 is an ALK inhibitor. It inhibits tumor growth in ALK positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroglastoma cells.
Product Unit Size | Cost | Quantity | Stock |
---|
CEP-28122 is an ALK inhibitor. It inhibits tumor growth in ALK positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroglastoma cells.
Cas No. | 1354545-57-5 |
---|---|
Purity | ≥98% |
Formula | C28H35ClN6O3 • CH4O3S |
Formula Wt. | 635.18 |
IUPAC Name | (1S,2S,3R,4R)-3-[(5-Chloro-2-{[(7S)-1-methoxy-7-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino}-4-pyrimidinyl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide methanesulfonate (1:1) |
Synonym | CEP 28122 Mesylate, CEP28122 Mesylate |
Solubility | 10 mM in DMSO |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Cheng M., Quail M., et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 11(3):670-79 (2012). PMID: 22203728.
Nucleoside (deoxyadenosine) analog; DNA chain t...
CDK2 inhibitor.
Triterpene saponin found in species of Panax.
NLRP3 and caspase-1 inhibitor.
BRD inhibitor.
Thiazole; proteasome inhibitor, protein translo...
Sesquiterpene alkaloid found in Huperzia serrat...
Rifampicin derivative; DNA-dependent RNA polyme...
Trichothecene mycotoxin produced by Fusarium.
Quinoline; PDE 3B inhibitor.
Labdane diterpene found in Coleus; PP2A and ade...
H+/K+ ATPase and Scpc phosphatase inhibitor.
Voltage-gated K+ channel blocker.
Inhibitor of Bcl-2 and Bcl-xL
T-type calcium channel blocker
mTOR activator.
Endogenous APP peptide cleavage product, primar...
Endogenous peptide hormone, involved in stress ...
Water-soluble cortisol derivative; glucocortico...
CRTH2 inhibitor.