Description
Cerivastatin is an inhibitor of HMG-CoA reductase that exhibits anti-hyperlipidemic, anti-atherosclerotic, anti-fibrotic, and anti-inflammatory activities. Cerivastatin has been used clinically to lower cholesterol and treat cardiovascular disease, but has since been withdrawn from the market due to associations with the development of rhabdomyolysis. In vitro, cerivastatin decreases production and activation of IL-6, AP-1, and NF-κB. In hepatocytes, this compound decreases TNF-α-induced production of PAI-1, preventing atherosclerosis and fibrosis.