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Chromomycin A3

Chromomycin A3

Product ID C2969
Cas No. 7059-24-7
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $90.30 In stock
5 mg $315.20 In stock
10 mg $563.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Chromomycin A3 is an anthraquinone that exhibits antibacterial and anticancer chemotherapeutic activity. Chromomycin A3 binds Mg2+ and Zn2+ ions, and these complexes bind GC sequences in nucleosomal DNA; this inhibits DNA gyrase, RNA polymerase, and DNA transcription. Chromomycin inhibits growth of bacteria such as Bacillus, inhibits alcohol dehydrogenase, and suppresses tumor growth of breast cancer xenografts in animal models.

Product Info

Cas No.

7059-24-7

Purity

≥97%

Formula

C57H82O26

Formula Wt.

1183.2488

IUPAC Name

[6-[[6-[4-[4-(5-acetyloxy-4-hydroxy-4, 6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6- methyloxan-2-yl]oxy-7-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-4, 10-dihydroxy-3-methyl-5-oxo-7, 8-dihydro-6H-anthracen-2-yl]oxy]-4-(4-hydroxy-5-methoxy-6-methyloxan-2- yl)oxy-2-methyloxan-3-yl] acetate

Melting Point

182-186°C

Appearance

Yellow Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C2969 MSDS PDF

Info Sheet

C2969 Info Sheet PDF

References

Devi PG, Chakraborty PK, Dasgupta D. Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3. J Biol Inorg Chem. 2009 Mar;14(3):347-59. PMID: 19034537.

Mir MA, Dasgupta D. Association of the anticancer antibiotic chromomycin A(3) with the nucleosome: role of core histone tail domains in the binding process. Biochemistry. 2001 Sep 25;40(38):11578-85. PMID: 11560508.

Simon H, Wittig B, Zimmer C. Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase. FEBS Lett. 1994 Oct 10;353(1):79-83. PMID: 7926028.

Inoue K, Fujimoto S, Ogawa M. Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Cancer Chemother Pharmacol. 1983;10(3):182-6. PMID: 6305523.

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