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Chromostatin is a peptide fragment representing chromogranin A (124-143). Chromostatin exhibits cardiomodulatory activity, inhibiting vasoconstriction in thoracic arteries and saphenous veins induced by K+, norepinephrine, and endothelin-1. Additionally, chromostatin inhibits catecholamine secretion in chromaffin cells through the activation of protein phosphatase 2A (PP2A).
| Cas No. | 133633-11-1 |
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| Purity | ≥95% |
| Formula | C78H120N24O35 |
| Formula Wt. | 1953.97 |
| Synonym | Chromogranin A (124-143); CgA; Pituitary Secretory Protein I; SP-I; CHGA; Cromostatin-20; CST. |
| Solubility | Soluble in water. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Garcia GE, Gabbai FB, O'Connor DT, et al. Does chromostatin influence catecholamine release or blood pressure in vivo? Peptides. 1994 Jan;15(1):195-7. PMID: 8015978.
Aardal S, Galindo E, Aunis D, et al. Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels. Regul Pept. 1993 Aug 13;47(1):25-32. PMID: 8210519.
Galindo E, Zwiller J, Bader MF, et al. Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphatase. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7398-402. PMID: 1323834.