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Cilnidipine

Cilnidipine

Product ID C3446
Cas No. 132203-70-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $110.40 In stock
100 mg $211.40 In stock
250 mg $352.30 In stock
1 g $1,014.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cilnidipine is a dihydropyridine that exhibits antihypertensive, vasodilatory, antinociceptive, and nephroprotective activities. Cilnidipine acts as an antagonist at L-type and N-type voltage-gated Ca2+ channels. In subjects with hypertension, cilnidipine decreases blood pressure and urinary albumin excretion. Cilnidipine also increases expression of eNOS ex vivo in thoracic arteries. In animal models of non insulin-dependent diabetes, cilnidipine improves insulin sensitivity, indicating potential anti-diabetic activity as well. This compound inhibits nociception in animal models undergoing the formalin test. Additionally, in vitro, cilnidipine decreases production of AP-1, TGF-β, and fibronectin, inhibiting proliferation of mesangial cells; in similar animal models, cilnidipine inhibits progression of glomerulonephritis.

Product Info

Cas No.

132203-70-4

Purity

≥98%

Formula

C27H28N2O7

Formula Wt.

492.52

IUPAC Name

3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Melting Point

97-99°C

Solubility

DMSO (>25 mg/mL), ethanol (20 mg/mL). Insoluble in water.

Appearance

Light yellow crystal powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C3446 MSDS PDF

Info Sheet

C3446 Info Sheet PDF

References

Soeki T, Kitani M, Kusunose K, et al. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. Hypertens Res. 2012 Nov;35(11):1058-62. PMID: 22763473.

Fan L, Yang Q, Xiao XQ, et al. Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. J Thorac Cardiovasc Surg. 2011 Apr;141(4):1063-9. PMID: 20599230.

Koganei H, Shoji M, Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull. 2009 Oct;32(10):1695-700. PMID: 19801830.

Sugiura T, Imai E, Moriyama T, et al. Calcium channel blockers inhibit proliferation and matrix production in rat mesangial cells: possible mechanism of suppression of AP-1 and CREB activities. Nephron. 2000 May;85(1):71-80. PMID: 10773759.

Harada N, Ohnaka M, Sakamoto S, et al. Cilnidipine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM. Cardiovasc Drugs Ther. 1999 Nov;13(6):519-23. PMID: 10686661.

Fan YY, Kohno M, Nakano D, et al. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens. 2010 May;28(5):1034-1043. PMID: 20411599.

Custom Order

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