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Ciprofloxacin is a second generation fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria. Ciprofloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA replication.
| Cas No. | 86393-32-0 |
|---|---|
| Purity | ≥98% |
| Formula | C17H18FN3O3 • HCl • H2O |
| Formula Wt. | 385.82 |
| Chemical Name | 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3- quinolinecarboxylic acid monohydrochloride |
| IUPAC Name | 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrate;hydrochloride |
| Synonym | CiproR, Ciflan, Floxacipron, Proxacin |
| Melting Point | 314-324°C |
| Solubility | Soluble in water (3.5 g/100 ml), ethanol (1.6 mg/ml). Reconstitute with suitable solvent. Aliquot and store at -20°C. Solutions should be protected from light. Reconstituted product is stable for 6 months at -20°C. |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Rajendram M, Hurley KA, Foss MH, et al. Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology. ACS Chem Biol. 2014 Apr 22. [Epub ahead of print]. PMID: 24712739.
Oliphant CM, Green GM. Quinolones: a comprehensive review. Am Fam Physician. 2002 Feb 1;65(3):455-64. PMID: 11858629.
Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.
Aldred KJ, McPherson SA, Wang P, et al. Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry. 2012 Jan 10;51(1):370-381. PMID: 22126453.